Development of recombinant VHH nanobodies as an alternative for clearance of equine arteritis virus in carrier stallions

In conclusion, a VHH library derived from llama B cells following immunization with EAV was generated. This novel strategy could allow the generation of EAV-specific neutralizing Nbs as a therapeutic approach to induce clearance of EAV carrier state in stallions.

Bibliographic Details
Authors: Aduriz Guerrero, Matí­as, Carossino, Mariano, Go, Y.Y., Vincke, Cécile, Balasuriya, Udeni B.R., Muyldermans, S., Wigdorovitz, Andres, Barrandeguy, Maria Edith, Parreño, Viviana
Format: article
Status:Published version
Publication Date:2016
Country:Argentina
Institution:Instituto Nacional de Tecnología Agropecuaria
Repository:INTA Digital (INTA)
Language:English
OAI Identifier:oai:localhost:20.500.12123/1009
Online Access:http://hdl.handle.net/20.500.12123/1009
http://www.j-evs.com/article/S0737-0806(16)00154-4/pdf
http://dx.doi.org/10.1016/j.jevs.2016.02.123
Access Level:Open access
Keyword:Animal Diseases
Stallions
Nanotechnology
Equine Arteritis Virus
Enfermedades de los Animales
Caballos Sementales
Nanotecnología
Virus de la Arteritis Equina
Description
Summary:In conclusion, a VHH library derived from llama B cells following immunization with EAV was generated. This novel strategy could allow the generation of EAV-specific neutralizing Nbs as a therapeutic approach to induce clearance of EAV carrier state in stallions.

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