Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting

Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, c...

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Bibliographic Details
Authors: Tasoglu, Savas, Safaee, Hooman, Zhang, Xiaohui, Kingsley, James L., Catalano, Paolo Nicolás, Gurkan, Umut Atakan, Nureddin, Aida, Kayaalp, Emre, Anchan, Raymond M., Maas, Richard L., Tüzel, Erkan, Demirci, Utkan
Format: article
Status:Published version
Publication Date:2013
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/3921
Online Access:http://hdl.handle.net/11336/3921
Access Level:Open access
Keyword:Sperm Exhaustion
Motility
Naturally Inspired Biodesign
Sperm Sorting
Microfluidic Sorting
Fertility
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
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Summary:Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.

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