How lipids may affect risk for suicidal behavior

Suicide and nonfatal suicidal behaviors are major causes of mortality and morbidity worldwide. Variability in rates of suicide and suicidal behaviors within and between countries has been attributed to population and individual risk factors, including economic status and cultural differences, both o...

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Detalles Bibliográficos
Autores: Daray, Federico Manuel, Mann, John, Sublette, M. Elizabeth
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/98225
Acceso en línea:http://hdl.handle.net/11336/98225
Access Level:acceso abierto
Palabra clave:Suicide
PUFA
cholesterol
serotonin
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
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spelling How lipids may affect risk for suicidal behaviorDaray, Federico ManuelMann, JohnSublette, M. ElizabethSuicidePUFAcholesterolserotoninhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Suicide and nonfatal suicidal behaviors are major causes of mortality and morbidity worldwide. Variability in rates of suicide and suicidal behaviors within and between countries has been attributed to population and individual risk factors, including economic status and cultural differences, both of which can have suicide risk effects mediated through a variety of factors, of which perhaps the least understood is the role of diet. We therefore review the scientific literature concerning two major dietary lipid classes, cholesterol and polyunsaturated fatty acids (PUFAs), that have been associated with higher risk of suicide attempts and suicide. We consider potential mechanistic intermediates including serotonin transporters and receptors, toll-like receptors (TLRs), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and peroxisome proliferator activated receptors (PPARs). Based on this review, we describe a theoretical model linking cholesterol and PUFA status to suicide risk, taking into account the effects of cholesterol-lowering interventions on PUFA balance, membrane lipid microdomains (rafts) as a nexus of interaction between cholesterol and omega-3 PUFAs, and downstream effects on serotonergic neurotransmission and specific inflammatory pathways.Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Mann, John. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados UnidosFil: Sublette, M. Elizabeth. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados UnidosPergamon-Elsevier Science Ltd2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98225Daray, Federico Manuel; Mann, John; Sublette, M. Elizabeth; How lipids may affect risk for suicidal behavior; Pergamon-Elsevier Science Ltd; Journal of Psychiatric Research; 104; 9-2018; 16-230022-3956CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpsychires.2018.06.007info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102068/info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022395617312505info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:06:26Zoai:ri.conicet.gov.ar:11336/98225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:06:26.427CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv How lipids may affect risk for suicidal behavior
title How lipids may affect risk for suicidal behavior
spellingShingle How lipids may affect risk for suicidal behavior
Daray, Federico Manuel
Suicide
PUFA
cholesterol
serotonin
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short How lipids may affect risk for suicidal behavior
title_full How lipids may affect risk for suicidal behavior
title_fullStr How lipids may affect risk for suicidal behavior
title_full_unstemmed How lipids may affect risk for suicidal behavior
title_sort How lipids may affect risk for suicidal behavior
dc.creator.none.fl_str_mv Daray, Federico Manuel
Mann, John
Sublette, M. Elizabeth
author Daray, Federico Manuel
author_facet Daray, Federico Manuel
Mann, John
Sublette, M. Elizabeth
author_role author
author2 Mann, John
Sublette, M. Elizabeth
author2_role author
author
dc.subject.none.fl_str_mv Suicide
PUFA
cholesterol
serotonin
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic Suicide
PUFA
cholesterol
serotonin
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description Suicide and nonfatal suicidal behaviors are major causes of mortality and morbidity worldwide. Variability in rates of suicide and suicidal behaviors within and between countries has been attributed to population and individual risk factors, including economic status and cultural differences, both of which can have suicide risk effects mediated through a variety of factors, of which perhaps the least understood is the role of diet. We therefore review the scientific literature concerning two major dietary lipid classes, cholesterol and polyunsaturated fatty acids (PUFAs), that have been associated with higher risk of suicide attempts and suicide. We consider potential mechanistic intermediates including serotonin transporters and receptors, toll-like receptors (TLRs), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and peroxisome proliferator activated receptors (PPARs). Based on this review, we describe a theoretical model linking cholesterol and PUFA status to suicide risk, taking into account the effects of cholesterol-lowering interventions on PUFA balance, membrane lipid microdomains (rafts) as a nexus of interaction between cholesterol and omega-3 PUFAs, and downstream effects on serotonergic neurotransmission and specific inflammatory pathways.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98225
Daray, Federico Manuel; Mann, John; Sublette, M. Elizabeth; How lipids may affect risk for suicidal behavior; Pergamon-Elsevier Science Ltd; Journal of Psychiatric Research; 104; 9-2018; 16-23
0022-3956
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98225
identifier_str_mv Daray, Federico Manuel; Mann, John; Sublette, M. Elizabeth; How lipids may affect risk for suicidal behavior; Pergamon-Elsevier Science Ltd; Journal of Psychiatric Research; 104; 9-2018; 16-23
0022-3956
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpsychires.2018.06.007
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102068/
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022395617312505
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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