Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients

Introduction: Osteolytic bone metastasis in advanced breast cancer stages are a major complication for patient´s quality life and a sign of low survival prognosis. Permissive microenvironments which allow cancer cell secondary homing and later proliferation are fundamental for metastatic processes....

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Detalles Bibliográficos
Autores: Fernández Vallone, Valeria Beatriz, Borzone, Francisco Raúl, Martinez, Leandro Marcelo, Giorello, Maria Belen, Choi, Hosoon, Dimase, Federico, Feldman, Leonardo, Bordenave, Raúl Horacio, Chudzinski Tavassi, Ana Marisa, Batagelj, Emilio, Chasseing, Norma Alejandra
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/216141
Acceso en línea:http://hdl.handle.net/11336/216141
Access Level:acceso abierto
Palabra clave:BONE METASTASIS
CCL-2
PRE-METASTATIC NICHE
RANKL
SPONTANEOUS OSTEOCLASTOGENESIS
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
id AR_a518fe917666e7174dffb671def718cf
oai_identifier_str oai:ri.conicet.gov.ar:11336/216141
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
title Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
spellingShingle Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
Fernández Vallone, Valeria Beatriz
BONE METASTASIS
CCL-2
PRE-METASTATIC NICHE
RANKL
SPONTANEOUS OSTEOCLASTOGENESIS
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
title_short Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
title_full Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
title_fullStr Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
title_full_unstemmed Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
title_sort Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients
dc.creator.none.fl_str_mv Fernández Vallone, Valeria Beatriz
Borzone, Francisco Raúl
Martinez, Leandro Marcelo
Giorello, Maria Belen
Choi, Hosoon
Dimase, Federico
Feldman, Leonardo
Bordenave, Raúl Horacio
Chudzinski Tavassi, Ana Marisa
Batagelj, Emilio
Chasseing, Norma Alejandra
author Fernández Vallone, Valeria Beatriz
author_facet Fernández Vallone, Valeria Beatriz
Borzone, Francisco Raúl
Martinez, Leandro Marcelo
Giorello, Maria Belen
Choi, Hosoon
Dimase, Federico
Feldman, Leonardo
Bordenave, Raúl Horacio
Chudzinski Tavassi, Ana Marisa
Batagelj, Emilio
Chasseing, Norma Alejandra
author_role author
author2 Borzone, Francisco Raúl
Martinez, Leandro Marcelo
Giorello, Maria Belen
Choi, Hosoon
Dimase, Federico
Feldman, Leonardo
Bordenave, Raúl Horacio
Chudzinski Tavassi, Ana Marisa
Batagelj, Emilio
Chasseing, Norma Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BONE METASTASIS
CCL-2
PRE-METASTATIC NICHE
RANKL
SPONTANEOUS OSTEOCLASTOGENESIS
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
topic BONE METASTASIS
CCL-2
PRE-METASTATIC NICHE
RANKL
SPONTANEOUS OSTEOCLASTOGENESIS
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
description Introduction: Osteolytic bone metastasis in advanced breast cancer stages are a major complication for patient´s quality life and a sign of low survival prognosis. Permissive microenvironments which allow cancer cell secondary homing and later proliferation are fundamental for metastatic processes. The causes and mechanisms behind bone metastasis in breast cancer patients are still an unsolved puzzle. Therefore, in this work we contribute to describe bone marrow pre-metastatic niche in advanced breast cancer patients. Results: We show an increase in osteoclasts precursors with a concomitant imbalance towards spontaneous osteoclastogenesis which can be evidenced at bone marrow and peripheral levels. Pro-osteoclastogenic factors RANKL and CCL-2 may contribute to bone resorption signature observed in bone marrow. Meanwhile, expression levels of specific microRNAs in primary breast tumors may already indicate a pro-osteoclastogenic scenario prior to bone metastasis. Discussion: The discovery of prognostic biomarkers and novel therapeutic targets linked to bone metastasis initiation and development are a promising perspective for preventive treatments and metastasis management in advanced breast cancer patients.
publishDate 2023
dc.date.none.fl_str_mv 2023-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216141
Fernández Vallone, Valeria Beatriz; Borzone, Francisco Raúl; Martinez, Leandro Marcelo; Giorello, Maria Belen; Choi, Hosoon; et al.; Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients; Frontiers Media; Frontiers in Oncology; 13; 2-2023; 1-17
2234-943X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216141
identifier_str_mv Fernández Vallone, Valeria Beatriz; Borzone, Francisco Raúl; Martinez, Leandro Marcelo; Giorello, Maria Belen; Choi, Hosoon; et al.; Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients; Frontiers Media; Frontiers in Oncology; 13; 2-2023; 1-17
2234-943X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2023.1073793
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195538583715840
spelling Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patientsFernández Vallone, Valeria BeatrizBorzone, Francisco RaúlMartinez, Leandro MarceloGiorello, Maria BelenChoi, HosoonDimase, FedericoFeldman, LeonardoBordenave, Raúl HoracioChudzinski Tavassi, Ana MarisaBatagelj, EmilioChasseing, Norma AlejandraBONE METASTASISCCL-2PRE-METASTATIC NICHERANKLSPONTANEOUS OSTEOCLASTOGENESIShttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Introduction: Osteolytic bone metastasis in advanced breast cancer stages are a major complication for patient´s quality life and a sign of low survival prognosis. Permissive microenvironments which allow cancer cell secondary homing and later proliferation are fundamental for metastatic processes. The causes and mechanisms behind bone metastasis in breast cancer patients are still an unsolved puzzle. Therefore, in this work we contribute to describe bone marrow pre-metastatic niche in advanced breast cancer patients. Results: We show an increase in osteoclasts precursors with a concomitant imbalance towards spontaneous osteoclastogenesis which can be evidenced at bone marrow and peripheral levels. Pro-osteoclastogenic factors RANKL and CCL-2 may contribute to bone resorption signature observed in bone marrow. Meanwhile, expression levels of specific microRNAs in primary breast tumors may already indicate a pro-osteoclastogenic scenario prior to bone metastasis. Discussion: The discovery of prognostic biomarkers and novel therapeutic targets linked to bone metastasis initiation and development are a promising perspective for preventive treatments and metastasis management in advanced breast cancer patients.Fil: Fernández Vallone, Valeria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Borzone, Francisco Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Giorello, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Choi, Hosoon. No especifíca;Fil: Dimase, Federico. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; ArgentinaFil: Feldman, Leonardo. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaFil: Bordenave, Raúl Horacio. Hospital Iriarte; ArgentinaFil: Chudzinski Tavassi, Ana Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Batagelj, Emilio. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; ArgentinaFil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFrontiers Media2023-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216141Fernández Vallone, Valeria Beatriz; Borzone, Francisco Raúl; Martinez, Leandro Marcelo; Giorello, Maria Belen; Choi, Hosoon; et al.; Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients; Frontiers Media; Frontiers in Oncology; 13; 2-2023; 1-172234-943XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2023.1073793info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:55:34Zoai:ri.conicet.gov.ar:11336/216141instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:55:34.867CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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