Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves

Copper (Cu) and zinc (Zn) deficiency may cause poor weight gain, hematological changes, and immune failure in extensive beef cattle breeding systems. Diagnosis of the deficiency is based on plasma Cu and Zn concentrations; however, there are discrepancies regarding data interpretation. Here, plasma...

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Autores: Mattioli, Guillermo Alberto, Rosa, Diana Esther, Turic, Esteban, Testa, Juan Alberto, Lizarraga, Raúl Martín, Fazzio, Luis Emilio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/135922
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/135922
Access Level:acceso abierto
Palabra clave:Veterinaria
Beef cattle
Trace elements
Diagnosis
Immune response
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spelling Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef CalvesMattioli, Guillermo AlbertoRosa, Diana EstherTuric, EstebanTesta, Juan AlbertoLizarraga, Raúl MartínFazzio, Luis EmilioVeterinariaBeef cattleTrace elementsDiagnosisImmune responseCopper (Cu) and zinc (Zn) deficiency may cause poor weight gain, hematological changes, and immune failure in extensive beef cattle breeding systems. Diagnosis of the deficiency is based on plasma Cu and Zn concentrations; however, there are discrepancies regarding data interpretation. Here, plasma Cu and Zn concentrations are discussed as risk markers. We evaluated the effect of parenteral Cu and Zn supplementation on their plasma concentrations, weight gain, hematological parameters, and antibody titers to bovine herpes virus 1 (BoHV-1). Pre-weaning calves (n = 40; 99 ± 8 kg bw) from a typical breeding area of Argentina with background Cu and Zn deficiency were used. They were assigned to two homogeneous groups in a completely randomized design. Calves were subcutaneously injected with 0.3 mg/kg Cu and 1 mg/kg Zn (supplemented group), or saline solution (control), every 40 days during 120 days. Plasma Cu and Zn concentrations, hematological parameters, and weight were recorded. On days 40 and 80 of the trial, calves were vaccinated with inactivated BoHV-1. Antibody immune response was measured on days 80 and 120. Data were analyzed with a mixed model for repeated measures over time. Before treatment, plasma Cu was low and Zn was adequate in both groups. After treatment, plasma Cu increased and remained within a normal range, whereas plasma Zn remained constant. Supplemented animals had higher weight gain (p < 0.01); higher hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin levels (p < 0.05); and higher immune response to BoHV-1 (p < 0.05). Our results suggest that Cu and Zn supplementation improved daily weight gain and the immune response of pre-weaning calves.Facultad de Ciencias Veterinarias2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf456-462http://sedici.unlp.edu.ar/handle/10915/135922enginfo:eu-repo/semantics/altIdentifier/issn/1559-0720info:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-018-1493-9info:eu-repo/semantics/altIdentifier/pmid/30196487info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:10:24Zoai:sedici.unlp.edu.ar:10915/135922Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:10:24.86SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
title Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
spellingShingle Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
Mattioli, Guillermo Alberto
Veterinaria
Beef cattle
Trace elements
Diagnosis
Immune response
title_short Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
title_full Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
title_fullStr Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
title_full_unstemmed Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
title_sort Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves
dc.creator.none.fl_str_mv Mattioli, Guillermo Alberto
Rosa, Diana Esther
Turic, Esteban
Testa, Juan Alberto
Lizarraga, Raúl Martín
Fazzio, Luis Emilio
author Mattioli, Guillermo Alberto
author_facet Mattioli, Guillermo Alberto
Rosa, Diana Esther
Turic, Esteban
Testa, Juan Alberto
Lizarraga, Raúl Martín
Fazzio, Luis Emilio
author_role author
author2 Rosa, Diana Esther
Turic, Esteban
Testa, Juan Alberto
Lizarraga, Raúl Martín
Fazzio, Luis Emilio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Veterinaria
Beef cattle
Trace elements
Diagnosis
Immune response
topic Veterinaria
Beef cattle
Trace elements
Diagnosis
Immune response
description Copper (Cu) and zinc (Zn) deficiency may cause poor weight gain, hematological changes, and immune failure in extensive beef cattle breeding systems. Diagnosis of the deficiency is based on plasma Cu and Zn concentrations; however, there are discrepancies regarding data interpretation. Here, plasma Cu and Zn concentrations are discussed as risk markers. We evaluated the effect of parenteral Cu and Zn supplementation on their plasma concentrations, weight gain, hematological parameters, and antibody titers to bovine herpes virus 1 (BoHV-1). Pre-weaning calves (n = 40; 99 ± 8 kg bw) from a typical breeding area of Argentina with background Cu and Zn deficiency were used. They were assigned to two homogeneous groups in a completely randomized design. Calves were subcutaneously injected with 0.3 mg/kg Cu and 1 mg/kg Zn (supplemented group), or saline solution (control), every 40 days during 120 days. Plasma Cu and Zn concentrations, hematological parameters, and weight were recorded. On days 40 and 80 of the trial, calves were vaccinated with inactivated BoHV-1. Antibody immune response was measured on days 80 and 120. Data were analyzed with a mixed model for repeated measures over time. Before treatment, plasma Cu was low and Zn was adequate in both groups. After treatment, plasma Cu increased and remained within a normal range, whereas plasma Zn remained constant. Supplemented animals had higher weight gain (p < 0.01); higher hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin levels (p < 0.05); and higher immune response to BoHV-1 (p < 0.05). Our results suggest that Cu and Zn supplementation improved daily weight gain and the immune response of pre-weaning calves.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/135922
url http://sedici.unlp.edu.ar/handle/10915/135922
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1559-0720
info:eu-repo/semantics/altIdentifier/issn/0163-4984
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-018-1493-9
info:eu-repo/semantics/altIdentifier/pmid/30196487
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
456-462
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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