Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study

Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state...

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Detalles Bibliográficos
Autores: Kemp, Andrew H., Rodríguez López, Santiago, Passos, Valeria M. A., Bittencourt, Marcio S., Dantas, Eduardo M., Mill, José G., Ribeiro, Antonio L. P., Thayer, Julian F., Bensenor, Isabela M., Lotufo, Paulo A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/85844
Acceso en línea:http://hdl.handle.net/11336/85844
Access Level:acceso abierto
Palabra clave:CAROTID INTIMA-MEDIA THICKNESS
COGNITION
EXECUTIVE FUNCTION
HEART RATE VARIABILITY
HOMA-IR
HOMEOSTASIS MODEL ASSESSMENT INDEX FOR INSULIN RESISTANCE
HRV
IMT
MEDIATION ANALYSES
PATH MODELLING
TMT
TRAIL MAKING TEST
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
Descripción
Sumario:Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.

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