Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications

Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes thissmall 14-kDa cytosolic protein one of the main...

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Detalhes bibliográficos
Autores: Alza, Natalia Paola, Iglesias González, Pablo Andrés, Conde, Melisa Ailén, Uranga, Romina Maria, Salvador, Gabriela Alejandra
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/99028
Acesso em linha:http://hdl.handle.net/11336/99028
Access Level:Acceso aberto
Palavra-chave:LIPID METABOLISM
LIPID SIGNAL TRANSDUCTION
LIPIDS
MEMBRANE LIPIDS
Alpha;-SYNUCLEIN
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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dc.title.none.fl_str_mv Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
title Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
spellingShingle Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
Alza, Natalia Paola
LIPID METABOLISM
LIPID SIGNAL TRANSDUCTION
LIPIDS
MEMBRANE LIPIDS
Alpha;-SYNUCLEIN
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
title_full Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
title_fullStr Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
title_full_unstemmed Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
title_sort Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
dc.creator.none.fl_str_mv Alza, Natalia Paola
Iglesias González, Pablo Andrés
Conde, Melisa Ailén
Uranga, Romina Maria
Salvador, Gabriela Alejandra
author Alza, Natalia Paola
author_facet Alza, Natalia Paola
Iglesias González, Pablo Andrés
Conde, Melisa Ailén
Uranga, Romina Maria
Salvador, Gabriela Alejandra
author_role author
author2 Iglesias González, Pablo Andrés
Conde, Melisa Ailén
Uranga, Romina Maria
Salvador, Gabriela Alejandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv LIPID METABOLISM
LIPID SIGNAL TRANSDUCTION
LIPIDS
MEMBRANE LIPIDS
Alpha;-SYNUCLEIN
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic LIPID METABOLISM
LIPID SIGNAL TRANSDUCTION
LIPIDS
MEMBRANE LIPIDS
Alpha;-SYNUCLEIN
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes thissmall 14-kDa cytosolic protein one of the main etiologic factors associated withdegenerative disorders known as synucleinopathies. The structure, function, and toxicityofα-synuclein and the possibility of different therapeutic approaches to target theprotein have been extensively investigated and reviewed. One intriguing characteristic ofα-synuclein is the different ways in which it interacts with lipids. Though in-depth studieshave been carried out in this field, the information they have produced is puzzling andthe precise role of lipids inα-synuclein biology and pathology andvice versais still largelyunknown. Here we provide an overview and discussion of the main findings relating toα-synuclein/lipid interaction and its involvement in the modulation of lipid metabolismand signaling.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99028
Alza, Natalia Paola; Iglesias González, Pablo Andrés; Conde, Melisa Ailén; Uranga, Romina Maria; Salvador, Gabriela Alejandra; Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications; Frontiers Media S.A.; Frontiers in Cellular Neuroscience; 13; 1-5-2019; 1-17
1662-5102
1663-4365
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99028
identifier_str_mv Alza, Natalia Paola; Iglesias González, Pablo Andrés; Conde, Melisa Ailén; Uranga, Romina Maria; Salvador, Gabriela Alejandra; Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications; Frontiers Media S.A.; Frontiers in Cellular Neuroscience; 13; 1-5-2019; 1-17
1662-5102
1663-4365
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fncel.2019.00175/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fncel.2019.00175
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196065919926272
spelling Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implicationsAlza, Natalia PaolaIglesias González, Pablo AndrésConde, Melisa AilénUranga, Romina MariaSalvador, Gabriela AlejandraLIPID METABOLISMLIPID SIGNAL TRANSDUCTIONLIPIDSMEMBRANE LIPIDSAlpha;-SYNUCLEINhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes thissmall 14-kDa cytosolic protein one of the main etiologic factors associated withdegenerative disorders known as synucleinopathies. The structure, function, and toxicityofα-synuclein and the possibility of different therapeutic approaches to target theprotein have been extensively investigated and reviewed. One intriguing characteristic ofα-synuclein is the different ways in which it interacts with lipids. Though in-depth studieshave been carried out in this field, the information they have produced is puzzling andthe precise role of lipids inα-synuclein biology and pathology andvice versais still largelyunknown. Here we provide an overview and discussion of the main findings relating toα-synuclein/lipid interaction and its involvement in the modulation of lipid metabolismand signaling.Fil: Alza, Natalia Paola. Universidad Nacional del Sur. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Iglesias González, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Conde, Melisa Ailén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Salvador, Gabriela Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFrontiers Media S.A.2019-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99028Alza, Natalia Paola; Iglesias González, Pablo Andrés; Conde, Melisa Ailén; Uranga, Romina Maria; Salvador, Gabriela Alejandra; Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications; Frontiers Media S.A.; Frontiers in Cellular Neuroscience; 13; 1-5-2019; 1-171662-51021663-4365CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fncel.2019.00175/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fncel.2019.00175info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:13:30Zoai:ri.conicet.gov.ar:11336/99028instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:13:31.231CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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