Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness

Gap-junction channels (GJCs) are formed by headto-head association of two hemichannels (HCs, connexin hexamers). HCs and GJCs are permeable to ions and hydrophilic molecules of up to Mr ~1 kDa. Hearing impairment of genetic origin is common, and mutations of connexin 26 (Cx26) are its major cause. W...

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Detalhes bibliográficos
Autores: Dalamon, Viviana Karina, Fiori, Mariana C., Figueroa, Vania A., Oliva, Carolina A., del Rio, Rodrigo, Gonzalez, Wendy, Canan, Jonathan, Elgoyhen, Ana Belen, Altenberg, Guillermo A., Retamal, Mauricio A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/44334
Acesso em linha:http://hdl.handle.net/11336/44334
Access Level:acceso abierto
Palavra-chave:Deafness
Connexins
Gap-Junction Channels
Mutation
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descrição
Resumo:Gap-junction channels (GJCs) are formed by headto-head association of two hemichannels (HCs, connexin hexamers). HCs and GJCs are permeable to ions and hydrophilic molecules of up to Mr ~1 kDa. Hearing impairment of genetic origin is common, and mutations of connexin 26 (Cx26) are its major cause. We recently identified two novel Cx26 mutations in hearing-impaired subjects, L10P and G109V. L10P forms functional GJCs with slightly altered voltage dependence and HCs with decrease ATP/cationic dye selectivity. G109V does not form functional GJCs, but forms functional HCs with enhanced extracellular Ca2+ sensitivity and subtle alterations in voltage dependence and ATP/ cationic dye selectivity. Deafness associated with G109V could result from decreased GJCs activity, whereas deafness associated to L10P may have a more complex mechanism that involves changes in HC permeability.