Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s
Cystic echinococcosis is a zoonotic disease caused by the parasite Echinococcus granulosus sensu lato (s.l.), which is worldwide distributed and causes long-lasting infections in animals and humans. The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ). However, it...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/211604 |
| Acceso en línea: | http://hdl.handle.net/11336/211604 |
| Access Level: | acceso abierto |
| Palabra clave: | Asteraceae Echinococcus granulosus Cystic echinococcosis https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
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| dc.title.none.fl_str_mv |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| title |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| spellingShingle |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s Albani, Clara Maria Asteraceae Echinococcus granulosus Cystic echinococcosis https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| title_short |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| title_full |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| title_fullStr |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| title_full_unstemmed |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| title_sort |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s |
| dc.creator.none.fl_str_mv |
Albani, Clara Maria Borgo, Jimena Fabbri, Julia Pensel, Patricia Eugenia Fasciani, L. Elso, Orlando German Papademetrio, Daniela Laura Grasso, Daniel Hector Paladini, A. Beer, Maria Florencia Farias, Nahuel Emiliano Elissondo, N. Gambino, G. Zoppi, J. Sülsen, Valeria Patricia Elissondo, María Celina |
| author |
Albani, Clara Maria |
| author_facet |
Albani, Clara Maria Borgo, Jimena Fabbri, Julia Pensel, Patricia Eugenia Fasciani, L. Elso, Orlando German Papademetrio, Daniela Laura Grasso, Daniel Hector Paladini, A. Beer, Maria Florencia Farias, Nahuel Emiliano Elissondo, N. Gambino, G. Zoppi, J. Sülsen, Valeria Patricia Elissondo, María Celina |
| author_role |
author |
| author2 |
Borgo, Jimena Fabbri, Julia Pensel, Patricia Eugenia Fasciani, L. Elso, Orlando German Papademetrio, Daniela Laura Grasso, Daniel Hector Paladini, A. Beer, Maria Florencia Farias, Nahuel Emiliano Elissondo, N. Gambino, G. Zoppi, J. Sülsen, Valeria Patricia Elissondo, María Celina |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Asteraceae Echinococcus granulosus Cystic echinococcosis https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| topic |
Asteraceae Echinococcus granulosus Cystic echinococcosis https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| description |
Cystic echinococcosis is a zoonotic disease caused by the parasite Echinococcus granulosus sensu lato (s.l.), which is worldwide distributed and causes long-lasting infections in animals and humans. The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ). However, it has unwanted side effects and its efficacy is about 50%. The Asteraceae family includes plants that have therapeutic applications (medicinal species) and has an important role in new drug development. The species belonging to a different genus of this family show a wide range of anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, and antiparasitic activities, among others. The aim of the present study was to evaluate the in vitro efficacy of extracts of four Asteraceae species against protoscoleces of E. granulosus sensu stricto (s.s.). On the other hand, the Stevia aristata extract was assessed on the murine cyst of E. granulosus (s.s.) and the efficacy of S. aristata extract was investigated in a murine model of CE. Stevia satureiifolia, S. aristata, Grindelia pulchella, and G. chiloensis extracts at 100 μg/mL caused a decrease in protoscoleces viability; however, S. aristata extract produced the greatest in vitro protoscolicidal effect. After 20 days of treatment with the highest concentration (100 μg/mL) of S. aristata extract, protoscoleces viability decreased to 0%. The tegumental changes observed by scanning electron microscopy were consistent with the reduction in vitality. The collapse of the germinal layer was registered in 60 ± 5.8% and 83.3 ± 12.0% of cysts treated during 4 days with 50 and 100 μg/ml, respectively. The half maximal effective concentration (EC50) value of the S. aristata extract against E. granulosus (s.s.) cysts was 47.86 μg/mL (96 h). The dosage of infected animals with the 50 mg kg-1 dose of S. aristata extract resulted in a significant reduction in cyst weight in comparison with the control group. In conclusion, S. aristata extract was demonstrated to exert a marked effect, both in vitro and in the murine model. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/211604 Albani, Clara Maria; Borgo, Jimena; Fabbri, Julia; Pensel, Patricia Eugenia; Fasciani, L.; et al.; Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s; Oxford University Press; Evidence-Based Complementary and Alternative Medicine; 2022; 9-2022; 1-10 1741-427X 1741-4288 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/211604 |
| identifier_str_mv |
Albani, Clara Maria; Borgo, Jimena; Fabbri, Julia; Pensel, Patricia Eugenia; Fasciani, L.; et al.; Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s; Oxford University Press; Evidence-Based Complementary and Alternative Medicine; 2022; 9-2022; 1-10 1741-427X 1741-4288 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ecam/2022/6371849/ info:eu-repo/semantics/altIdentifier/doi/10.1155/2022/6371849 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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application/pdf application/pdf application/pdf application/pdf application/pdf |
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Oxford University Press |
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Oxford University Press |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1799195924711342080 |
| spelling |
Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.sAlbani, Clara MariaBorgo, JimenaFabbri, JuliaPensel, Patricia EugeniaFasciani, L.Elso, Orlando GermanPapademetrio, Daniela LauraGrasso, Daniel HectorPaladini, A.Beer, Maria FlorenciaFarias, Nahuel EmilianoElissondo, N.Gambino, G.Zoppi, J.Sülsen, Valeria PatriciaElissondo, María CelinaAsteraceaeEchinococcus granulosusCystic echinococcosishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cystic echinococcosis is a zoonotic disease caused by the parasite Echinococcus granulosus sensu lato (s.l.), which is worldwide distributed and causes long-lasting infections in animals and humans. The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ). However, it has unwanted side effects and its efficacy is about 50%. The Asteraceae family includes plants that have therapeutic applications (medicinal species) and has an important role in new drug development. The species belonging to a different genus of this family show a wide range of anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, and antiparasitic activities, among others. The aim of the present study was to evaluate the in vitro efficacy of extracts of four Asteraceae species against protoscoleces of E. granulosus sensu stricto (s.s.). On the other hand, the Stevia aristata extract was assessed on the murine cyst of E. granulosus (s.s.) and the efficacy of S. aristata extract was investigated in a murine model of CE. Stevia satureiifolia, S. aristata, Grindelia pulchella, and G. chiloensis extracts at 100 μg/mL caused a decrease in protoscoleces viability; however, S. aristata extract produced the greatest in vitro protoscolicidal effect. After 20 days of treatment with the highest concentration (100 μg/mL) of S. aristata extract, protoscoleces viability decreased to 0%. The tegumental changes observed by scanning electron microscopy were consistent with the reduction in vitality. The collapse of the germinal layer was registered in 60 ± 5.8% and 83.3 ± 12.0% of cysts treated during 4 days with 50 and 100 μg/ml, respectively. The half maximal effective concentration (EC50) value of the S. aristata extract against E. granulosus (s.s.) cysts was 47.86 μg/mL (96 h). The dosage of infected animals with the 50 mg kg-1 dose of S. aristata extract resulted in a significant reduction in cyst weight in comparison with the control group. In conclusion, S. aristata extract was demonstrated to exert a marked effect, both in vitro and in the murine model.Fil: Albani, Clara Maria. Universidad Nacional de Mar del Plata. Instituto de Investigaciones En Produccion, Sanidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mar del Plata. Instituto de Investigaciones En Produccion, Sanidad y Ambiente.; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; ArgentinaFil: Borgo, Jimena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Fabbri, Julia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina. Universidad Nacional de Mar del Plata. Facultad de Cs.exactas y Naturales. Instituto de Investigaciones En Sanidad Produccion y Ambiente. - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires. Instituto de Investigaciones En Sanidad Produccion y Ambiente.; ArgentinaFil: Pensel, Patricia Eugenia. Universidad Nacional de Mar del Plata. Facultad de Cs.exactas y Naturales. Instituto de Investigaciones En Sanidad Produccion y Ambiente. - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires. Instituto de Investigaciones En Sanidad Produccion y Ambiente.; ArgentinaFil: Fasciani, L.. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; ArgentinaFil: Elso, Orlando German. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacognosia; ArgentinaFil: Papademetrio, Daniela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Grasso, Daniel Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Paladini, A.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Parasitología y Enfermedades Parasitarias; ArgentinaFil: Beer, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Farias, Nahuel Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Elissondo, N.. No especifíca;Fil: Gambino, G.. No especifíca;Fil: Zoppi, J.. No especifíca;Fil: Sülsen, Valeria Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacognosia; ArgentinaFil: Elissondo, María Celina. Universidad Nacional de Mar del Plata. Facultad de Cs.exactas y Naturales. Instituto de Investigaciones En Sanidad Produccion y Ambiente. - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires. Instituto de Investigaciones En Sanidad Produccion y Ambiente.; ArgentinaOxford University Press2022-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211604Albani, Clara Maria; Borgo, Jimena; Fabbri, Julia; Pensel, Patricia Eugenia; Fasciani, L.; et al.; Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s; Oxford University Press; Evidence-Based Complementary and Alternative Medicine; 2022; 9-2022; 1-101741-427X1741-4288CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ecam/2022/6371849/info:eu-repo/semantics/altIdentifier/doi/10.1155/2022/6371849info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:08:25Zoai:ri.conicet.gov.ar:11336/211604instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:08:25.679CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
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15.811543 |