Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice

Metabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet-lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in...

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Detalles Bibliográficos
Autores: Casiraghi, Leandro P., Alzamendi, Ana, Giovambattista, Andrés, Chiesa, Juan J., Golombek, Diego Andrés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/86255
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86255
Access Level:acceso abierto
Palabra clave:Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
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spelling Effects of chronic forced circadian desynchronization on body weight and metabolism in male miceCasiraghi, Leandro P.Alzamendi, AnaGiovambattista, AndrésChiesa, Juan J.Golombek, Diego AndrésBiologíaChronic jet-lagCircadian disruptionRestricted feedingShift workWheel-runningMetabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet-lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in C57Bl/6 mice under chronic 6 h advances or delays of the light-dark cycle every 2 days (ChrA and ChrD, respectively). We have previously reported ChrA, but not ChrD, to induce forced desynchronization of locomotor activity rhythms in mice (Casiraghi et al. ). Body weight was rapidly increased under ChrA, with animals tripling the mean weight gain observed in controls by day 10, and doubling it by day 30 (6% vs. 2%, and 15% vs. 7%, respectively). Significant increases in retroperitoneal and epidydimal adipose tissue masses (172% and 61%, respectively), adipocytes size (28%), and circulating triglycerides (39%) were also detected. Daily patterns of food and water intake were abolished under ChrA. In contrast, ChrD had no effect on body weight. Wheel-running, housing of animals in groups, and restriction of food availability to hours of darkness prevented abnormal increase in body weight under ChrA. Our findings suggest that the observed alterations under ChrA may arise either from a direct effect of circadian disruption on metabolism, from desynchronization between feeding and metabolic rhythms, or both. Direction of shifts, timing of feeding episodes, and other reinforcing signals deeply affect the outcome of metabolic function under CJL. Such features should be taken into account in further studies of shift working schedules in humans.Instituto Multidisciplinario de Biología Celular2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/86255enginfo:eu-repo/semantics/altIdentifier/issn/2051-817Xinfo:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.12743info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T12:54:43Zoai:sedici.unlp.edu.ar:10915/86255Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 12:54:43.319SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
spellingShingle Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
Casiraghi, Leandro P.
Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
title_short Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_full Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_fullStr Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_full_unstemmed Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_sort Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
dc.creator.none.fl_str_mv Casiraghi, Leandro P.
Alzamendi, Ana
Giovambattista, Andrés
Chiesa, Juan J.
Golombek, Diego Andrés
author Casiraghi, Leandro P.
author_facet Casiraghi, Leandro P.
Alzamendi, Ana
Giovambattista, Andrés
Chiesa, Juan J.
Golombek, Diego Andrés
author_role author
author2 Alzamendi, Ana
Giovambattista, Andrés
Chiesa, Juan J.
Golombek, Diego Andrés
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
topic Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
description Metabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet-lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in C57Bl/6 mice under chronic 6 h advances or delays of the light-dark cycle every 2 days (ChrA and ChrD, respectively). We have previously reported ChrA, but not ChrD, to induce forced desynchronization of locomotor activity rhythms in mice (Casiraghi et al. ). Body weight was rapidly increased under ChrA, with animals tripling the mean weight gain observed in controls by day 10, and doubling it by day 30 (6% vs. 2%, and 15% vs. 7%, respectively). Significant increases in retroperitoneal and epidydimal adipose tissue masses (172% and 61%, respectively), adipocytes size (28%), and circulating triglycerides (39%) were also detected. Daily patterns of food and water intake were abolished under ChrA. In contrast, ChrD had no effect on body weight. Wheel-running, housing of animals in groups, and restriction of food availability to hours of darkness prevented abnormal increase in body weight under ChrA. Our findings suggest that the observed alterations under ChrA may arise either from a direct effect of circadian disruption on metabolism, from desynchronization between feeding and metabolic rhythms, or both. Direction of shifts, timing of feeding episodes, and other reinforcing signals deeply affect the outcome of metabolic function under CJL. Such features should be taken into account in further studies of shift working schedules in humans.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86255
url http://sedici.unlp.edu.ar/handle/10915/86255
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2051-817X
info:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.12743
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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