Green one-pot synthesis of 2H-pyrans under solvent-free conditions catalyzed by ethylenediammonium diacetate
Ethylenediammonium diacetate readily catalyzes the Knoevenagel-type condensation between 1,3-dicarbonyl substrates and α,β-unsaturated aldehydes at room temperature under solvent-free conditions. This rapid, efficient, and convenient one-pot approach to the synthesis of 2H-pyrans stands as a signifi...
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/6133 |
| Acceso en línea: | http://hdl.handle.net/11336/6133 |
| Access Level: | acceso abierto |
| Palabra clave: | Green Chemistry Solvent-Free Domino Reactions 2h-Pyrans https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Ethylenediammonium diacetate readily catalyzes the Knoevenagel-type condensation between 1,3-dicarbonyl substrates and α,β-unsaturated aldehydes at room temperature under solvent-free conditions. This rapid, efficient, and convenient one-pot approach to the synthesis of 2H-pyrans stands as a significant advance over previously reported protocols. This environmentally friendly methodology has been successfully applied to the synthesis of biologically active natural products of interest zanthosimuline, N-methylflindersine, and ferprenin. |
|---|