Observable effects of Ca2+ buffers on local Ca2+ signals
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have pr...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | Argentina |
| Institución: | Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
| Repositorio: | Biblioteca Digital (UBA-FCEN) |
| Idioma: | inglés |
| OAI Identifier: | paperaa:paper_1364503X_v368_n1933_p5597_Solovey |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey |
| Access Level: | acceso abierto |
| Palabra clave: | Buffers Puffs Sugars Transport properties High resolution Local signal Optical experiments Physiological process Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability |
| Sumario: | Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society. |
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