Larrea divaricata Cav (Jarilla): Production of superoxide anion, hydrogen peroxide and expression of zymosan receptors

Larrea divaricata is a plant widely used in folk medicine in Argentina. This work aimed to study the mechanisms of decoction activity on the release of oxygen reactive species. Decoction increased the binding of zymosan-FITC and superoxide production. Cadmium decreased the superoxide production as w...

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Detalles Bibliográficos
Autores: Davicino, Roberto Carlos, Martinez, Carolina, Mattar Domínguez, María Aída, Casali, Judith Yolanda, Correa, Silvia Graciela, Aragón, Leslie Mary, Saidman, Elbio Antonio, Messina, Germán Alejandro, Micalizzi, Blas
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/159801
Acceso en línea:http://hdl.handle.net/11336/159801
Access Level:acceso abierto
Palabra clave:DECOCTION
HYDROGEN PEROXIDE
LARREA DIVARICATA
SUPEROXIDE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descripción
Sumario:Larrea divaricata is a plant widely used in folk medicine in Argentina. This work aimed to study the mechanisms of decoction activity on the release of oxygen reactive species. Decoction increased the binding of zymosan-FITC and superoxide production. Cadmium decreased the superoxide production as well as malonate and barbital. Decoction decreased the release of hydrogen peroxide. Decoction increased the reduction of MTT but not when malonate and barbital were included. Together, decoction increased the expression of dectin-1 leading to increased superoxide production. It is possible that decoction increases the activity of peroxidase, and decreases the Cu, Zn-superoxide dismutase.

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