Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data

Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Met...

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Autores: Narata, Ana Paula, Obradó, Laura, Moyano, Raquel Kalé, Macho, Juan M., Blasco, Jordi, Rueda, Antonio López, Roman, Luis San, Remollo, Sebastian, Marinelli, Claudia Beatriz, Cepeda, Rosana, Fernández, Héctor, Larrabide, Ignacio
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/164520
Acesso em linha:http://hdl.handle.net/11336/164520
Access Level:Acceso aberto
Palavra-chave:CEREBRAL ANEURYSMS
FLOW DIVERTER
DEVICE SIZING
DEVICE POROSITY
TIME-TO-OCCLUSION
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
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oai_identifier_str oai:ri.conicet.gov.ar:11336/164520
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network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
title Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
spellingShingle Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
Narata, Ana Paula
CEREBRAL ANEURYSMS
FLOW DIVERTER
DEVICE SIZING
DEVICE POROSITY
TIME-TO-OCCLUSION
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
title_short Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
title_full Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
title_fullStr Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
title_full_unstemmed Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
title_sort Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
dc.creator.none.fl_str_mv Narata, Ana Paula
Obradó, Laura
Moyano, Raquel Kalé
Macho, Juan M.
Blasco, Jordi
Rueda, Antonio López
Roman, Luis San
Remollo, Sebastian
Marinelli, Claudia Beatriz
Cepeda, Rosana
Fernández, Héctor
Larrabide, Ignacio
author Narata, Ana Paula
author_facet Narata, Ana Paula
Obradó, Laura
Moyano, Raquel Kalé
Macho, Juan M.
Blasco, Jordi
Rueda, Antonio López
Roman, Luis San
Remollo, Sebastian
Marinelli, Claudia Beatriz
Cepeda, Rosana
Fernández, Héctor
Larrabide, Ignacio
author_role author
author2 Obradó, Laura
Moyano, Raquel Kalé
Macho, Juan M.
Blasco, Jordi
Rueda, Antonio López
Roman, Luis San
Remollo, Sebastian
Marinelli, Claudia Beatriz
Cepeda, Rosana
Fernández, Héctor
Larrabide, Ignacio
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CEREBRAL ANEURYSMS
FLOW DIVERTER
DEVICE SIZING
DEVICE POROSITY
TIME-TO-OCCLUSION
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
topic CEREBRAL ANEURYSMS
FLOW DIVERTER
DEVICE SIZING
DEVICE POROSITY
TIME-TO-OCCLUSION
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
description Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164520
Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-11
2673-3129
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164520
identifier_str_mv Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-11
2673-3129
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmedt.2021.705003/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmedt.2021.705003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195456050298880
spelling Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world dataNarata, Ana PaulaObradó, LauraMoyano, Raquel KaléMacho, Juan M.Blasco, JordiRueda, Antonio LópezRoman, Luis SanRemollo, SebastianMarinelli, Claudia BeatrizCepeda, RosanaFernández, HéctorLarrabide, IgnacioCEREBRAL ANEURYSMSFLOW DIVERTERDEVICE SIZINGDEVICE POROSITYTIME-TO-OCCLUSIONhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required.Fil: Narata, Ana Paula. Hôpitaux de Tours; FranciaFil: Obradó, Laura. Galgo Medical S. L.; EspañaFil: Moyano, Raquel Kalé. Galgo Medical S. L.; EspañaFil: Macho, Juan M.. Hospital Clinic of Barcelona; EspañaFil: Blasco, Jordi. Hospital Clinic of Barcelona; EspañaFil: Rueda, Antonio López. Hospital Clinic of Barcelona; EspañaFil: Roman, Luis San. Hospital Clinic of Barcelona; EspañaFil: Remollo, Sebastian. Hospital Universitari Germans Trias i Pujol; EspañaFil: Marinelli, Claudia Beatriz. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaFil: Cepeda, Rosana. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaFil: Fernández, Héctor. Galgo Medical S. L.; EspañaFil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina. Galgo Medical S. L.; EspañaFrontiers Media2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164520Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-112673-3129CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmedt.2021.705003/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmedt.2021.705003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:53:06Zoai:ri.conicet.gov.ar:11336/164520instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:53:06.639CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,812429

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