Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats

Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalatio...

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Detalhes bibliográficos
Autores: Ruiz, Paul, Calliari, Aldo, Genovese, Patricia, Scorza, Cecilia, Pautassi, Ricardo Marcos
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/96867
Acesso em linha:http://hdl.handle.net/11336/96867
Access Level:Acceso aberto
Palavra-chave:ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96867
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, ratsRuiz, PaulCalliari, AldoGenovese, PatriciaScorza, CeciliaPautassi, Ricardo MarcosADOLESCENCEAMPHETAMINEETHANOLMETHYLPHENIDATEMOTOR BEHAVIORhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; UruguayFil: Calliari, Aldo. Universidad de la República; UruguayFil: Genovese, Patricia. Universidad de la República; UruguayFil: Scorza, Cecilia. Instituto de Investigaciones Biológicas "Clemente Estable"; UruguayFil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaJohn Wiley & Sons Ltd2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96867Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-132162-3279CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/brb3.939info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.939info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:33:23Zoai:ri.conicet.gov.ar:11336/96867instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:33:23.956CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
spellingShingle Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
Ruiz, Paul
ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_full Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_fullStr Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_full_unstemmed Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_sort Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
dc.creator.none.fl_str_mv Ruiz, Paul
Calliari, Aldo
Genovese, Patricia
Scorza, Cecilia
Pautassi, Ricardo Marcos
author Ruiz, Paul
author_facet Ruiz, Paul
Calliari, Aldo
Genovese, Patricia
Scorza, Cecilia
Pautassi, Ricardo Marcos
author_role author
author2 Calliari, Aldo
Genovese, Patricia
Scorza, Cecilia
Pautassi, Ricardo Marcos
author2_role author
author
author
author
dc.subject.none.fl_str_mv ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96867
Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-13
2162-3279
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96867
identifier_str_mv Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-13
2162-3279
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/brb3.939
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.939
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194642127781888
score 15.811543

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