Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens

Macroautophagy is a self-degradative process that normally maintains cellular homeostasis via a lysosomal pathway. It is induced by different stress signals, including nutrients and growth factors’ restriction as well as pathogen invasions. These stimuli are modulated by the serine/threonine protein...

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Authors: Fader Kaiser, Claudio Marcelo, Aguilera, Milton Osmar, Colombo, Maria Isabel
Format: article
Status:Published version
Publication Date:2014
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/32010
Online Access:http://hdl.handle.net/11336/32010
Access Level:Open access
Keyword:Autophagy
Mtor
Amino Acids
Pathogens
Lc3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogensFader Kaiser, Claudio MarceloAguilera, Milton OsmarColombo, Maria IsabelAutophagyMtorAmino AcidsPathogensLc3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Macroautophagy is a self-degradative process that normally maintains cellular homeostasis via a lysosomal pathway. It is induced by different stress signals, including nutrients and growth factors’ restriction as well as pathogen invasions. These stimuli are modulated by the serine/threonine protein kinase mammalian target of rapamycin (mTOR) which control not only autophagy but also protein translation and gene expression. This review focuses on the important role of mTOR as a master regulator of cell growth and the autophagy pathway. Here, we have discussed the role of intracellular amino acid availability and intracellular pH in the redistribution of autophagic structures, which may contribute to mammalian target of rapamycin complex 1 (mTORC1) activity regulation. We have also discussed that mTORC1 complex and components of the autophagy machinery are localized at the lysosomal surface, representing a fascinating mechanism to control the metabolism, cellular clearance and also to restrain invading intracellular pathogens.Fil: Fader Kaiser, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Aguilera, Milton Osmar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaSpringer Wien2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32010Colombo, Maria Isabel; Aguilera, Milton Osmar; Fader Kaiser, Claudio Marcelo; Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens; Springer Wien; Amino Acids; 47; 10; 9-2014; 2101-21120939-44511438-2199CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00726-014-1835-7info:eu-repo/semantics/altIdentifier/doi/10.1007/s00726-014-1835-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:39:26Zoai:ri.conicet.gov.ar:11336/32010instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:39:26.821CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
title Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
spellingShingle Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
Fader Kaiser, Claudio Marcelo
Autophagy
Mtor
Amino Acids
Pathogens
Lc3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
title_full Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
title_fullStr Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
title_full_unstemmed Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
title_sort Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
dc.creator.none.fl_str_mv Fader Kaiser, Claudio Marcelo
Aguilera, Milton Osmar
Colombo, Maria Isabel
author Fader Kaiser, Claudio Marcelo
author_facet Fader Kaiser, Claudio Marcelo
Aguilera, Milton Osmar
Colombo, Maria Isabel
author_role author
author2 Aguilera, Milton Osmar
Colombo, Maria Isabel
author2_role author
author
dc.subject.none.fl_str_mv Autophagy
Mtor
Amino Acids
Pathogens
Lc3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Autophagy
Mtor
Amino Acids
Pathogens
Lc3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Macroautophagy is a self-degradative process that normally maintains cellular homeostasis via a lysosomal pathway. It is induced by different stress signals, including nutrients and growth factors’ restriction as well as pathogen invasions. These stimuli are modulated by the serine/threonine protein kinase mammalian target of rapamycin (mTOR) which control not only autophagy but also protein translation and gene expression. This review focuses on the important role of mTOR as a master regulator of cell growth and the autophagy pathway. Here, we have discussed the role of intracellular amino acid availability and intracellular pH in the redistribution of autophagic structures, which may contribute to mammalian target of rapamycin complex 1 (mTORC1) activity regulation. We have also discussed that mTORC1 complex and components of the autophagy machinery are localized at the lysosomal surface, representing a fascinating mechanism to control the metabolism, cellular clearance and also to restrain invading intracellular pathogens.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32010
Colombo, Maria Isabel; Aguilera, Milton Osmar; Fader Kaiser, Claudio Marcelo; Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens; Springer Wien; Amino Acids; 47; 10; 9-2014; 2101-2112
0939-4451
1438-2199
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32010
identifier_str_mv Colombo, Maria Isabel; Aguilera, Milton Osmar; Fader Kaiser, Claudio Marcelo; Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens; Springer Wien; Amino Acids; 47; 10; 9-2014; 2101-2112
0939-4451
1438-2199
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00726-014-1835-7
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00726-014-1835-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Wien
publisher.none.fl_str_mv Springer Wien
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194932675608576
score 15.808905

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