Physicochemical characterization of 2-hydroxybenzophenone with β-cyclodextrin in solution and solid state

The characterization of the inclusion complex between 2-hydroxybenzophenone (2OHBP) and β-cyclodextrin (βCD) in the solid state was performed using Fourier transform infrared spectroscopy (FTIR), powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis...

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Bibliographic Details
Authors: Sancho, Matias Israel, Russo, Marcos Guillermo, Moreno, Mario Sergio Jesus, Gasull, Estela Isabel, Blanco, Sonia Encarnacion, Narda, Griselda Edith
Format: article
Status:Published version
Publication Date:2015
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/127073
Online Access:http://hdl.handle.net/11336/127073
Access Level:Open access
Keyword:BENZOPHENONE
CYCLODEXTRINS
SOLUBILITY
INCLUSION COMPLEX
THERMAL ANALYSIS
MOLECULAR MODELING
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Description
Summary:The characterization of the inclusion complex between 2-hydroxybenzophenone (2OHBP) and β-cyclodextrin (βCD) in the solid state was performed using Fourier transform infrared spectroscopy (FTIR), powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The apparent formation constant of the complex was determined by phase solubility diagrams and liquid chromatography (HPLC) at different temperatures. The formation of the inclusion complex induced slight shifts in the FTIR spectrum while by PXRD a new crystalline phase was observed. TEM studies revealed that the complex forms aggregates of nanometric size. The inclusion complex showed a higher solubility in the tested dissolution media than free 2OHBP. Moreover, the freeze-dried solid complex exhibits a higher thermal stability than the solid free drug. The thermodynamic analysis allowed us to conclude that the encapsulation process is endothermic in water and exothermic in methanol-water.

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