Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling

Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson´s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequentl...

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Autores: Cardona Londoño, Juan Felipe, Gershanik, Oscar Samuel, Gelormini Lezama, Carlos, Lee Houck, Alexander, Cardona, Sebastián, Kargieman, Lucila, Trujillo, Natalia, Arévalo, Analía, Amoruso, Lucía, Manes, Facundo Francisco, Ibañez, Agustin Mariano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/22828
Acceso en línea:http://hdl.handle.net/11336/22828
Access Level:acceso abierto
Palabra clave:Parkinson´S Disease
Action-Verb Processing
Basal Ganglia
Motor-Language Coupling
Mirror Neurons
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22828
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
title Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
spellingShingle Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
Cardona Londoño, Juan Felipe
Parkinson´S Disease
Action-Verb Processing
Basal Ganglia
Motor-Language Coupling
Mirror Neurons
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
title_full Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
title_fullStr Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
title_full_unstemmed Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
title_sort Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
dc.creator.none.fl_str_mv Cardona Londoño, Juan Felipe
Gershanik, Oscar Samuel
Gelormini Lezama, Carlos
Lee Houck, Alexander
Cardona, Sebastián
Kargieman, Lucila
Trujillo, Natalia
Arévalo, Analía
Amoruso, Lucía
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author Cardona Londoño, Juan Felipe
author_facet Cardona Londoño, Juan Felipe
Gershanik, Oscar Samuel
Gelormini Lezama, Carlos
Lee Houck, Alexander
Cardona, Sebastián
Kargieman, Lucila
Trujillo, Natalia
Arévalo, Analía
Amoruso, Lucía
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author_role author
author2 Gershanik, Oscar Samuel
Gelormini Lezama, Carlos
Lee Houck, Alexander
Cardona, Sebastián
Kargieman, Lucila
Trujillo, Natalia
Arévalo, Analía
Amoruso, Lucía
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Parkinson´S Disease
Action-Verb Processing
Basal Ganglia
Motor-Language Coupling
Mirror Neurons
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic Parkinson´S Disease
Action-Verb Processing
Basal Ganglia
Motor-Language Coupling
Mirror Neurons
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson´s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical-subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action-perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22828
Cardona Londoño, Juan Felipe; Gershanik, Oscar Samuel; Gelormini Lezama, Carlos; Lee Houck, Alexander; Cardona, Sebastián; et al.; Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling; Springer Heidelberg; Brain Structure & Function; 218; 6; 2-2013; 1355-1373
1863-2653
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22828
identifier_str_mv Cardona Londoño, Juan Felipe; Gershanik, Oscar Samuel; Gelormini Lezama, Carlos; Lee Houck, Alexander; Cardona, Sebastián; et al.; Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling; Springer Heidelberg; Brain Structure & Function; 218; 6; 2-2013; 1355-1373
1863-2653
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00429-013-0510-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Heidelberg
publisher.none.fl_str_mv Springer Heidelberg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195489518747648
spelling Action-verb processing in Parkinson’s disease: new pathways for motor–language couplingCardona Londoño, Juan FelipeGershanik, Oscar SamuelGelormini Lezama, CarlosLee Houck, AlexanderCardona, SebastiánKargieman, LucilaTrujillo, NataliaArévalo, AnalíaAmoruso, LucíaManes, Facundo FranciscoIbañez, Agustin MarianoParkinson´S DiseaseAction-Verb ProcessingBasal GangliaMotor-Language CouplingMirror Neuronshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson´s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical-subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action-perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.Fil: Cardona Londoño, Juan Felipe. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Universidad Favaloro; ArgentinaFil: Gershanik, Oscar Samuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Gelormini Lezama, Carlos. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Lee Houck, Alexander. University of Tennessee; Estados UnidosFil: Cardona, Sebastián. Universidad de Caldas; ColombiaFil: Kargieman, Lucila. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Trujillo, Natalia. Universidad de Antioquía; ColombiaFil: Arévalo, Analía. Universidad de la República; UruguayFil: Amoruso, Lucía. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Manes, Facundo Francisco. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; ArgentinaFil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaSpringer Heidelberg2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22828Cardona Londoño, Juan Felipe; Gershanik, Oscar Samuel; Gelormini Lezama, Carlos; Lee Houck, Alexander; Cardona, Sebastián; et al.; Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling; Springer Heidelberg; Brain Structure & Function; 218; 6; 2-2013; 1355-13731863-2653CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00429-013-0510-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:54:05Zoai:ri.conicet.gov.ar:11336/22828instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:54:05.971CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,812429

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