Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).

The relationship between anticoagulant rodenticides and the gene for vitamin K epoxide reductase has been extensively studied. The significance of mutations in Vkorc1 on the degree of response to anticoagulants is controversial. The implication of the VKORC1 function in pest control drives the atten...

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Detalhes bibliográficos
Autor: Espinosa, Maria Beatriz
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2013
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/1395
Acesso em linha:http://hdl.handle.net/11336/1395
Access Level:Acceso aberto
Palavra-chave:VITAMIN K EPOXIDE REDUCTASE
RODENTICIDES
VKORC1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/4.1
https://purl.org/becyt/ford/4
id AR_8b232f8b3b06ef44211f0bb3ff27e6dd
oai_identifier_str oai:ri.conicet.gov.ar:11336/1395
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).Espinosa, Maria BeatrizVITAMIN K EPOXIDE REDUCTASERODENTICIDESVKORC1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/4.1https://purl.org/becyt/ford/4The relationship between anticoagulant rodenticides and the gene for vitamin K epoxide reductase has been extensively studied. The significance of mutations in Vkorc1 on the degree of response to anticoagulants is controversial. The implication of the VKORC1 function in pest control drives the attention to a wide range of factors that may be influencing the resistance to rodenticides, an issue that will be discussed in this article. Anticoagulants are used as rodenticides as well as to improve human health. The interactions between Vkorc1 and Cyp4f18 (cytochrome P450) are complex. It is likely that the coagulation response may be due to a diverse expression of the Vkorc1 gene and its interaction with the expression of Cyp4f18, and to the polymorphisms present in both genes. We analyzed the presence of polymorphisms (especially the presence of mutations that produce substitutions of Tyr139Cys and Leu128Ser) in Vkorc1 of the genome of Mus musculus belonging to local wild populations living in farms. The animals studied were from areas in which rodenticide anticoagulants (ej. bromadiolone) are commonly used as pest control. None of the studied mice showed any signs of anticoagulant resistance-related mutations in the Vkorc1 gene. This study will enable a proper selection of the rodenticide method for pest control in local areas. Key words: Vitamin K epoxide reductase, rodenticides, rodents.Fil: Espinosa, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Parque Centenario. Instituto de Investigaciones en Biociencias Agricolas y Ambientales; Argentina;Revista de la Sociedad Argentina de Genética.2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1395Espinosa, Maria Beatriz; Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).; Revista de la Sociedad Argentina de Genética.; Journal of Basic and Applied Genetics; 24; 1; 7-2013; 27-311852-6233enginfo:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332013000100004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:50:01Zoai:ri.conicet.gov.ar:11336/1395instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:50:02.162CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
title Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
spellingShingle Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
Espinosa, Maria Beatriz
VITAMIN K EPOXIDE REDUCTASE
RODENTICIDES
VKORC1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/4.1
https://purl.org/becyt/ford/4
title_short Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
title_full Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
title_fullStr Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
title_full_unstemmed Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
title_sort Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
dc.creator.none.fl_str_mv Espinosa, Maria Beatriz
author Espinosa, Maria Beatriz
author_facet Espinosa, Maria Beatriz
author_role author
dc.subject.none.fl_str_mv VITAMIN K EPOXIDE REDUCTASE
RODENTICIDES
VKORC1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/4.1
https://purl.org/becyt/ford/4
topic VITAMIN K EPOXIDE REDUCTASE
RODENTICIDES
VKORC1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/4.1
https://purl.org/becyt/ford/4
description The relationship between anticoagulant rodenticides and the gene for vitamin K epoxide reductase has been extensively studied. The significance of mutations in Vkorc1 on the degree of response to anticoagulants is controversial. The implication of the VKORC1 function in pest control drives the attention to a wide range of factors that may be influencing the resistance to rodenticides, an issue that will be discussed in this article. Anticoagulants are used as rodenticides as well as to improve human health. The interactions between Vkorc1 and Cyp4f18 (cytochrome P450) are complex. It is likely that the coagulation response may be due to a diverse expression of the Vkorc1 gene and its interaction with the expression of Cyp4f18, and to the polymorphisms present in both genes. We analyzed the presence of polymorphisms (especially the presence of mutations that produce substitutions of Tyr139Cys and Leu128Ser) in Vkorc1 of the genome of Mus musculus belonging to local wild populations living in farms. The animals studied were from areas in which rodenticide anticoagulants (ej. bromadiolone) are commonly used as pest control. None of the studied mice showed any signs of anticoagulant resistance-related mutations in the Vkorc1 gene. This study will enable a proper selection of the rodenticide method for pest control in local areas. Key words: Vitamin K epoxide reductase, rodenticides, rodents.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1395
Espinosa, Maria Beatriz; Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).; Revista de la Sociedad Argentina de Genética.; Journal of Basic and Applied Genetics; 24; 1; 7-2013; 27-31
1852-6233
url http://hdl.handle.net/11336/1395
identifier_str_mv Espinosa, Maria Beatriz; Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).; Revista de la Sociedad Argentina de Genética.; Journal of Basic and Applied Genetics; 24; 1; 7-2013; 27-31
1852-6233
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332013000100004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Revista de la Sociedad Argentina de Genética.
publisher.none.fl_str_mv Revista de la Sociedad Argentina de Genética.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.812429

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