Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two d...

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Detalhes bibliográficos
Autores: Rodriguez-Tudela, Juan Luis, Gomez-Lopez, Alicia, Arendrup, Maiken C., Garcia, Guillermo Manuel, Perlin, David S., Lass-Flörl, Cornelia, Cuenca-Estrella, Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/97694
Acesso em linha:http://hdl.handle.net/11336/97694
Access Level:acceso abierto
Palavra-chave:Echinocandinas
Resistencia
Evaluación sensibilidad
Caspofungina
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
Descrição
Resumo:According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

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