Factors related to orthostatic hypotension in Parkinson's disease

Introduction: Orthostatic hypotension (OH), a frequent feature of Parkinson's disease (PD) can contribute to falls and is usually related to the disease itself and/or to drugs. Objectives: To explore factors related to OH and to assess the concordance between abnormal blood pressure (BP) fall a...

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Autores: Perez Lloret, Santiago, Rey, María Verónica, Fabre, Nelly, Ory, Fabienne, Spampinato, Umberto, Senard, Jean Michel, Pavy Le Traon, Anne, Montastruc, Jean Louis, Rascol, Olivier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/196465
Acceso en línea:http://hdl.handle.net/11336/196465
Access Level:acceso abierto
Palabra clave:AGING
AMANTADINE
DIURETICS
ENTACAPONE
NON-MOTOR SYMPTOMS
ORTHOSTATIC HYPOTENSION
PARKINSON'S DISEASE
POLYPHARMACY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
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spelling Factors related to orthostatic hypotension in Parkinson's diseasePerez Lloret, SantiagoRey, María VerónicaFabre, NellyOry, FabienneSpampinato, UmbertoSenard, Jean MichelPavy Le Traon, AnneMontastruc, Jean LouisRascol, OlivierAGINGAMANTADINEDIURETICSENTACAPONENON-MOTOR SYMPTOMSORTHOSTATIC HYPOTENSIONPARKINSON'S DISEASEPOLYPHARMACYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Orthostatic hypotension (OH), a frequent feature of Parkinson's disease (PD) can contribute to falls and is usually related to the disease itself and/or to drugs. Objectives: To explore factors related to OH and to assess the concordance between abnormal blood pressure (BP) fall after standing and the presence of orthostatic symptoms. Methods: Non-demented, non-operated idiopathic PD out-patients were questioned about the presence of orthostatic symptoms. Afterward, BP was measured 5-min after lying down and for 3-min after standing up. OH was defined as systolic and/or diastolic BP fall ≥20 and/or 10. mmHg after standing. Patients were further evaluated by the Unified PD Rating Scale (UPDRS) and their medications were recorded. Results: 103 patients were included in this study (mean age = 66 ± 1 years, mean disease duration = 9 ± 1 years; mean UPDRS II. +. III in ON-state = 37 ± 2 points). Forty-one subjects (40%) reported the presence of orthostatic symptoms during the previous week and 38 (37%) had OH according to manometric definition. Independent factors related to OH, as assessed by logistic regression were age >68 years (OR, 95% CI = 3.61, 1.31-9.95), polypharmacy (defined as intake of >5 medications, OR = 3.59, 1.33-9.69), amantadine (7.45, 1.91-29.07) or diuretics (5.48, 1.10-54.76), whereas the consumption of entacapone was protective (0.20, 0.05-0.76). The agreement between abnormal BP fall and presence of orthostatic symptoms was poor (kappa = 0.12 ± 0.1, p= 0.23). Conclusion: OH was significantly related to older age, polypharmacy and amantadine or diuretics intake, while entacapone exposure appeared to reduce the risk of OH. Low concordance between OH and orthostatic symptoms was observed.Fil: Perez Lloret, Santiago. Inserm; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rey, María Verónica. Inserm; FranciaFil: Fabre, Nelly. Hôpital Purpan; FranciaFil: Ory, Fabienne. Hôpital Purpan; FranciaFil: Spampinato, Umberto. Inserm; FranciaFil: Senard, Jean Michel. Inserm; FranciaFil: Pavy Le Traon, Anne. Hôpital Purpan; FranciaFil: Montastruc, Jean Louis. Inserm; FranciaFil: Rascol, Olivier. Inserm; FranciaElsevier2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196465Perez Lloret, Santiago; Rey, María Verónica; Fabre, Nelly; Ory, Fabienne; Spampinato, Umberto; et al.; Factors related to orthostatic hypotension in Parkinson's disease; Elsevier; Parkinsonism & Related Disorders; 18; 5; 6-2012; 501-5051353-8020CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.prd-journal.com/article/S1353-8020(12)00030-2/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.parkreldis.2012.01.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:38:17Zoai:ri.conicet.gov.ar:11336/196465instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:38:17.431CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Factors related to orthostatic hypotension in Parkinson's disease
title Factors related to orthostatic hypotension in Parkinson's disease
spellingShingle Factors related to orthostatic hypotension in Parkinson's disease
Perez Lloret, Santiago
AGING
AMANTADINE
DIURETICS
ENTACAPONE
NON-MOTOR SYMPTOMS
ORTHOSTATIC HYPOTENSION
PARKINSON'S DISEASE
POLYPHARMACY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Factors related to orthostatic hypotension in Parkinson's disease
title_full Factors related to orthostatic hypotension in Parkinson's disease
title_fullStr Factors related to orthostatic hypotension in Parkinson's disease
title_full_unstemmed Factors related to orthostatic hypotension in Parkinson's disease
title_sort Factors related to orthostatic hypotension in Parkinson's disease
dc.creator.none.fl_str_mv Perez Lloret, Santiago
Rey, María Verónica
Fabre, Nelly
Ory, Fabienne
Spampinato, Umberto
Senard, Jean Michel
Pavy Le Traon, Anne
Montastruc, Jean Louis
Rascol, Olivier
author Perez Lloret, Santiago
author_facet Perez Lloret, Santiago
Rey, María Verónica
Fabre, Nelly
Ory, Fabienne
Spampinato, Umberto
Senard, Jean Michel
Pavy Le Traon, Anne
Montastruc, Jean Louis
Rascol, Olivier
author_role author
author2 Rey, María Verónica
Fabre, Nelly
Ory, Fabienne
Spampinato, Umberto
Senard, Jean Michel
Pavy Le Traon, Anne
Montastruc, Jean Louis
Rascol, Olivier
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AGING
AMANTADINE
DIURETICS
ENTACAPONE
NON-MOTOR SYMPTOMS
ORTHOSTATIC HYPOTENSION
PARKINSON'S DISEASE
POLYPHARMACY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic AGING
AMANTADINE
DIURETICS
ENTACAPONE
NON-MOTOR SYMPTOMS
ORTHOSTATIC HYPOTENSION
PARKINSON'S DISEASE
POLYPHARMACY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description Introduction: Orthostatic hypotension (OH), a frequent feature of Parkinson's disease (PD) can contribute to falls and is usually related to the disease itself and/or to drugs. Objectives: To explore factors related to OH and to assess the concordance between abnormal blood pressure (BP) fall after standing and the presence of orthostatic symptoms. Methods: Non-demented, non-operated idiopathic PD out-patients were questioned about the presence of orthostatic symptoms. Afterward, BP was measured 5-min after lying down and for 3-min after standing up. OH was defined as systolic and/or diastolic BP fall ≥20 and/or 10. mmHg after standing. Patients were further evaluated by the Unified PD Rating Scale (UPDRS) and their medications were recorded. Results: 103 patients were included in this study (mean age = 66 ± 1 years, mean disease duration = 9 ± 1 years; mean UPDRS II. +. III in ON-state = 37 ± 2 points). Forty-one subjects (40%) reported the presence of orthostatic symptoms during the previous week and 38 (37%) had OH according to manometric definition. Independent factors related to OH, as assessed by logistic regression were age >68 years (OR, 95% CI = 3.61, 1.31-9.95), polypharmacy (defined as intake of >5 medications, OR = 3.59, 1.33-9.69), amantadine (7.45, 1.91-29.07) or diuretics (5.48, 1.10-54.76), whereas the consumption of entacapone was protective (0.20, 0.05-0.76). The agreement between abnormal BP fall and presence of orthostatic symptoms was poor (kappa = 0.12 ± 0.1, p= 0.23). Conclusion: OH was significantly related to older age, polypharmacy and amantadine or diuretics intake, while entacapone exposure appeared to reduce the risk of OH. Low concordance between OH and orthostatic symptoms was observed.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196465
Perez Lloret, Santiago; Rey, María Verónica; Fabre, Nelly; Ory, Fabienne; Spampinato, Umberto; et al.; Factors related to orthostatic hypotension in Parkinson's disease; Elsevier; Parkinsonism & Related Disorders; 18; 5; 6-2012; 501-505
1353-8020
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196465
identifier_str_mv Perez Lloret, Santiago; Rey, María Verónica; Fabre, Nelly; Ory, Fabienne; Spampinato, Umberto; et al.; Factors related to orthostatic hypotension in Parkinson's disease; Elsevier; Parkinsonism & Related Disorders; 18; 5; 6-2012; 501-505
1353-8020
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.prd-journal.com/article/S1353-8020(12)00030-2/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.parkreldis.2012.01.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194868287799296
score 15.812429

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