Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found th...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Argentina |
| Institución: | Universidad Nacional de La Plata |
| Repositorio: | SEDICI (UNLP) |
| Idioma: | inglés |
| OAI Identifier: | oai:sedici.unlp.edu.ar:10915/104747 |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/104747 |
| Access Level: | acceso abierto |
| Palabra clave: | Ciencias Exactas Química oxidovanadium(IV) dipyrido[3,2-a:2',3'-c]phenazine (dppz) metallointercalators human osteosarcoma cell line |
| Sumario: | The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized. |
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