Synthesis of N-benzenesulfonylbenzotriazole derivatives, and evaluation of their antimicrobial activity
A series of benzenesulfonyl compounds, 1a-i, containing a BZT moiety was synthesized and characterized, and their antifungal and antibacterial activities were investigated. Compounds la and 1d showed the highest activity against Escherichia coli ATCC 25922; in addition la presented bactericidal acti...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/64435 |
| Acceso en línea: | http://hdl.handle.net/11336/64435 |
| Access Level: | acceso abierto |
| Palabra clave: | Antibacterial Antifungal Benzenesulfonyl Benzotriazole https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| Sumario: | A series of benzenesulfonyl compounds, 1a-i, containing a BZT moiety was synthesized and characterized, and their antifungal and antibacterial activities were investigated. Compounds la and 1d showed the highest activity against Escherichia coli ATCC 25922; in addition la presented bactericidal activity against E. coli and Staphylococcus aureus at 8.6 mM. The ability of la to generate superoxide anion (O2-) was measured and it showed more stimuli in S. aureus compared to sulfafhiazole, indicating that 1a can be involved in oxidative stress of bacteria. None of the compounds inhibited the growth of the dermatophytes strains at the tested concentration (250 μg/ml). © 2008 Bentham Science Publishers Ltd. |
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