Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents

Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of vertebrate plasma membranes. Changes in the expre...

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Authors: Daniotti, Jose Luis, Lardone, Ricardo Dante, Vilcaes, Aldo Alejandro
Format: article
Status:Published version
Publication Date:2016
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/51890
Online Access:http://hdl.handle.net/11336/51890
Access Level:Open access
Keyword:ANTIBODIES
CANCER
GANGLIOSIDES
GLYCOLIPIDS
IMMUNOTHERAPY
IMMUNOTOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/51890
network_acronym_str AR
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repository_id_str
spelling Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic AgentsDaniotti, Jose LuisLardone, Ricardo DanteVilcaes, Aldo AlejandroANTIBODIESCANCERGANGLIOSIDESGLYCOLIPIDSIMMUNOTHERAPYIMMUNOTOXINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of vertebrate plasma membranes. Changes in the expression of certain species of gangliosides have been described to occur during cell proliferation, differentiation, and ontogenesis. However, the aberrant and elevated expression of gangliosides has been also observed in different types of cancer cells, thereby promoting tumor survival. Moreover, gangliosides are actively released from the membrane of tumor cells, having a strong impact on impairing anti-tumor immunity. Beyond the undesirable effects of gangliosides in cancer cells, a substantial number of cancer immunotherapies have been developed in recent years that have used gangliosides as the main target. This has resulted in successful immune cell- or antibody-responses against glycolipids, with promising results having been obtained in clinical trials. In this review, we provide a general overview on the metabolism of glycolipids, both in normal and tumor cells, as well as examining glycolipid-mediated immune modulation and the main successes achieved in immunotherapies using gangliosides as molecular targets.Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Lardone, Ricardo Dante. The John Wayne Cancer Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vilcaes, Aldo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFrontiers Research Foundation2016-01-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51890Daniotti, Jose Luis; Lardone, Ricardo Dante; Vilcaes, Aldo Alejandro; Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents; Frontiers Research Foundation; Frontiers in Oncology; 5; 7-1-2016; 300-3002234-943XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2015.00300info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2015.00300/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:38:50Zoai:ri.conicet.gov.ar:11336/51890instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:38:51.157CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
title Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
spellingShingle Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
Daniotti, Jose Luis
ANTIBODIES
CANCER
GANGLIOSIDES
GLYCOLIPIDS
IMMUNOTHERAPY
IMMUNOTOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
title_full Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
title_fullStr Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
title_full_unstemmed Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
title_sort Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents
dc.creator.none.fl_str_mv Daniotti, Jose Luis
Lardone, Ricardo Dante
Vilcaes, Aldo Alejandro
author Daniotti, Jose Luis
author_facet Daniotti, Jose Luis
Lardone, Ricardo Dante
Vilcaes, Aldo Alejandro
author_role author
author2 Lardone, Ricardo Dante
Vilcaes, Aldo Alejandro
author2_role author
author
dc.subject.none.fl_str_mv ANTIBODIES
CANCER
GANGLIOSIDES
GLYCOLIPIDS
IMMUNOTHERAPY
IMMUNOTOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic ANTIBODIES
CANCER
GANGLIOSIDES
GLYCOLIPIDS
IMMUNOTHERAPY
IMMUNOTOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of vertebrate plasma membranes. Changes in the expression of certain species of gangliosides have been described to occur during cell proliferation, differentiation, and ontogenesis. However, the aberrant and elevated expression of gangliosides has been also observed in different types of cancer cells, thereby promoting tumor survival. Moreover, gangliosides are actively released from the membrane of tumor cells, having a strong impact on impairing anti-tumor immunity. Beyond the undesirable effects of gangliosides in cancer cells, a substantial number of cancer immunotherapies have been developed in recent years that have used gangliosides as the main target. This has resulted in successful immune cell- or antibody-responses against glycolipids, with promising results having been obtained in clinical trials. In this review, we provide a general overview on the metabolism of glycolipids, both in normal and tumor cells, as well as examining glycolipid-mediated immune modulation and the main successes achieved in immunotherapies using gangliosides as molecular targets.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/51890
Daniotti, Jose Luis; Lardone, Ricardo Dante; Vilcaes, Aldo Alejandro; Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents; Frontiers Research Foundation; Frontiers in Oncology; 5; 7-1-2016; 300-300
2234-943X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/51890
identifier_str_mv Daniotti, Jose Luis; Lardone, Ricardo Dante; Vilcaes, Aldo Alejandro; Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents; Frontiers Research Foundation; Frontiers in Oncology; 5; 7-1-2016; 300-300
2234-943X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2015.00300
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2015.00300/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,811543

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