A model to understand type I oxidations of biomolecules photosensitized by pterins
Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in r...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Argentina |
| Institución: | Universidad Nacional de La Plata |
| Repositorio: | SEDICI (UNLP) |
| Idioma: | inglés |
| OAI Identifier: | oai:sedici.unlp.edu.ar:10915/160474 |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/160474 |
| Access Level: | acceso abierto |
| Palabra clave: | Química Biología pterins photosensitization singlet oxygen radicals photooxidation |
| Sumario: | Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed. |
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