Endocannabinoids in TNF-α and ethanol actions

During marijuana and alcohol consumption as well as during inflammation the reproductive axis is inhibited, mainly through the inhibition of luteinizing hormone-releasing hormone release. In male rats, this inhibitory effect is mediated, at least in part, by the activation of hypothalamic cannabinoi...

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Autores: Besuhli, Valeria, Fernández Solari, José Javier, Prestifilippo, Juan Pablo, Mohn, Claudia Ester, de Laurentiis, Andrea, Bornstein, Stefan R., Ehrhart Bornstein, Monika, Elverdín, Juan Carlos, McCann Samuel M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/20326
Acesso em linha:http://hdl.handle.net/11336/20326
Access Level:acceso abierto
Palavra-chave:Hypothalamus
Submandibular Gland
Cb1 Receptor
Am251
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_7c24ecaecabfb6ba2f5003fa9846d847
oai_identifier_str oai:ri.conicet.gov.ar:11336/20326
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Endocannabinoids in TNF-α and ethanol actions
title Endocannabinoids in TNF-α and ethanol actions
spellingShingle Endocannabinoids in TNF-α and ethanol actions
Besuhli, Valeria
Hypothalamus
Submandibular Gland
Cb1 Receptor
Am251
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Endocannabinoids in TNF-α and ethanol actions
title_full Endocannabinoids in TNF-α and ethanol actions
title_fullStr Endocannabinoids in TNF-α and ethanol actions
title_full_unstemmed Endocannabinoids in TNF-α and ethanol actions
title_sort Endocannabinoids in TNF-α and ethanol actions
dc.creator.none.fl_str_mv Besuhli, Valeria
Fernández Solari, José Javier
Prestifilippo, Juan Pablo
Mohn, Claudia Ester
de Laurentiis, Andrea
Bornstein, Stefan R.
Ehrhart Bornstein, Monika
Elverdín, Juan Carlos
McCann Samuel M.
author Besuhli, Valeria
author_facet Besuhli, Valeria
Fernández Solari, José Javier
Prestifilippo, Juan Pablo
Mohn, Claudia Ester
de Laurentiis, Andrea
Bornstein, Stefan R.
Ehrhart Bornstein, Monika
Elverdín, Juan Carlos
McCann Samuel M.
author_role author
author2 Fernández Solari, José Javier
Prestifilippo, Juan Pablo
Mohn, Claudia Ester
de Laurentiis, Andrea
Bornstein, Stefan R.
Ehrhart Bornstein, Monika
Elverdín, Juan Carlos
McCann Samuel M.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hypothalamus
Submandibular Gland
Cb1 Receptor
Am251
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Hypothalamus
Submandibular Gland
Cb1 Receptor
Am251
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description During marijuana and alcohol consumption as well as during inflammation the reproductive axis is inhibited, mainly through the inhibition of luteinizing hormone-releasing hormone release. In male rats, this inhibitory effect is mediated, at least in part, by the activation of hypothalamic cannabinoid type 1 receptors (CB1). During inflammation, this activation of the endocannabinoid system seems to be mediated by an increase in TNF-α production followed by anandamide augmentations, similarly the effect of intragastric administration of ethanol (3 g/kg) seems to be due to an increase in anandamide. On the other hand, a number of different actions mediated by the endocannabinoid system in various organs and tissues have been described. Both cannabinoid receptors, CB1 and CB2, are localized in the submandibular gland where they mediate the inhibitory effect of intrasubmandibular injections of the endocannabinoid anandamide (6 × 10–5M) on salivary secretion. Lipopolysaccharide (5 mg/kg/3 h) injected intraperitoneally and ethanol (3 g/kg/1 h) injected intragastrically inhibited the salivary secretion induced by the sialogogue metacholine; this inhibitory effect was blocked by CB1 and/or CB2 receptor antagonists. Similar to the hypothalamus, these effects seem to be mediated by increased anandamide. In summary, similar mechanisms mediate the inhibitory actions of endocannabinoids and cannabinoids in both hypothalamus and submandibular gland during drug consumption and inflammation.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20326
Besuhli, Valeria; Fernández Solari, José Javier; Prestifilippo, Juan Pablo; Mohn, Claudia Ester; de Laurentiis, Andrea; et al.; Endocannabinoids in TNF-α and ethanol actions; Karger; Neuroimmunomodulation; 14; 3-4; 12-2007; 188-192
1021-7401
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20326
identifier_str_mv Besuhli, Valeria; Fernández Solari, José Javier; Prestifilippo, Juan Pablo; Mohn, Claudia Ester; de Laurentiis, Andrea; et al.; Endocannabinoids in TNF-α and ethanol actions; Karger; Neuroimmunomodulation; 14; 3-4; 12-2007; 188-192
1021-7401
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/110645
info:eu-repo/semantics/altIdentifier/doi/10.1159/000110645
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195505391042560
spelling Endocannabinoids in TNF-α and ethanol actionsBesuhli, ValeriaFernández Solari, José JavierPrestifilippo, Juan PabloMohn, Claudia Esterde Laurentiis, AndreaBornstein, Stefan R.Ehrhart Bornstein, MonikaElverdín, Juan CarlosMcCann Samuel M.HypothalamusSubmandibular GlandCb1 ReceptorAm251https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3During marijuana and alcohol consumption as well as during inflammation the reproductive axis is inhibited, mainly through the inhibition of luteinizing hormone-releasing hormone release. In male rats, this inhibitory effect is mediated, at least in part, by the activation of hypothalamic cannabinoid type 1 receptors (CB1). During inflammation, this activation of the endocannabinoid system seems to be mediated by an increase in TNF-α production followed by anandamide augmentations, similarly the effect of intragastric administration of ethanol (3 g/kg) seems to be due to an increase in anandamide. On the other hand, a number of different actions mediated by the endocannabinoid system in various organs and tissues have been described. Both cannabinoid receptors, CB1 and CB2, are localized in the submandibular gland where they mediate the inhibitory effect of intrasubmandibular injections of the endocannabinoid anandamide (6 × 10–5M) on salivary secretion. Lipopolysaccharide (5 mg/kg/3 h) injected intraperitoneally and ethanol (3 g/kg/1 h) injected intragastrically inhibited the salivary secretion induced by the sialogogue metacholine; this inhibitory effect was blocked by CB1 and/or CB2 receptor antagonists. Similar to the hypothalamus, these effects seem to be mediated by increased anandamide. In summary, similar mechanisms mediate the inhibitory actions of endocannabinoids and cannabinoids in both hypothalamus and submandibular gland during drug consumption and inflammation.Fil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Prestifilippo, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Mohn, Claudia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Bornstein, Stefan R.. University of Dresden; AlemaniaFil: Ehrhart Bornstein, Monika. University of Dresden; AlemaniaFil: Elverdín, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: McCann Samuel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaKarger2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20326Besuhli, Valeria; Fernández Solari, José Javier; Prestifilippo, Juan Pablo; Mohn, Claudia Ester; de Laurentiis, Andrea; et al.; Endocannabinoids in TNF-α and ethanol actions; Karger; Neuroimmunomodulation; 14; 3-4; 12-2007; 188-1921021-7401CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/110645info:eu-repo/semantics/altIdentifier/doi/10.1159/000110645info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:54:34Zoai:ri.conicet.gov.ar:11336/20326instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:54:35.13CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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