Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite

Hsp90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated following stressful events and has been involved in many cellular processes. In T...

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Detalles Bibliográficos
Autores: Ángel, Sergio Oscar, Figueras López, María Julia, Alomar, María Lis, Echeverria, Pablo Christian, Deng, Bin
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/24700
Acceso en línea:http://hdl.handle.net/11336/24700
Access Level:acceso abierto
Palabra clave:Toxoplasma Gondii
Hsp90
Cell Cycle
Post-Translational Modification
Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24700
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
title Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
spellingShingle Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
Ángel, Sergio Oscar
Toxoplasma Gondii
Hsp90
Cell Cycle
Post-Translational Modification
Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
title_full Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
title_fullStr Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
title_full_unstemmed Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
title_sort Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite
dc.creator.none.fl_str_mv Ángel, Sergio Oscar
Figueras López, María Julia
Alomar, María Lis
Echeverria, Pablo Christian
Deng, Bin
author Ángel, Sergio Oscar
author_facet Ángel, Sergio Oscar
Figueras López, María Julia
Alomar, María Lis
Echeverria, Pablo Christian
Deng, Bin
author_role author
author2 Figueras López, María Julia
Alomar, María Lis
Echeverria, Pablo Christian
Deng, Bin
author2_role author
author
author
author
dc.subject.none.fl_str_mv Toxoplasma Gondii
Hsp90
Cell Cycle
Post-Translational Modification
Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Toxoplasma Gondii
Hsp90
Cell Cycle
Post-Translational Modification
Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Hsp90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated following stressful events and has been involved in many cellular processes. In Toxoplasma gondii, Hsp90 could be linked with many essential processes of the parasite such as host cell invasion, replication and tachyzoite-bradyzoite interconversion. A Protein-Protein Interaction (PPI) network approach of TgHsp90 has allowed inferring how these processes may be altered. In addition, data mining of T. gondii phosphoproteome and acetylome has allowed the generation of the phosphorylation and acetylation map of TgHsp90. This review focuses on the potential roles of TgHsp90 in parasite biology and the analysis of experimental data in comparison with its counterparts in yeast and humans.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24700
Ángel, Sergio Oscar; Figueras López, María Julia; Alomar, María Lis; Echeverria, Pablo Christian; Deng, Bin; Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite; Cambridge University Press; Parasitology; 141; 9; 1-2014; 1138-1147
0031-1820
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24700
identifier_str_mv Ángel, Sergio Oscar; Figueras López, María Julia; Alomar, María Lis; Echeverria, Pablo Christian; Deng, Bin; Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite; Cambridge University Press; Parasitology; 141; 9; 1-2014; 1138-1147
0031-1820
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1017/S0031182014000055
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/parasitology/article/toxoplasma-gondii-hsp90-potential-roles-in-essential-cellular-processes-of-the-parasite/FEA49F3900F342B278F70683F7A43CB9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196461680820224
spelling Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasiteÁngel, Sergio OscarFigueras López, María JuliaAlomar, María LisEcheverria, Pablo ChristianDeng, BinToxoplasma GondiiHsp90Cell CyclePost-Translational ModificationDevelopmenthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Hsp90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated following stressful events and has been involved in many cellular processes. In Toxoplasma gondii, Hsp90 could be linked with many essential processes of the parasite such as host cell invasion, replication and tachyzoite-bradyzoite interconversion. A Protein-Protein Interaction (PPI) network approach of TgHsp90 has allowed inferring how these processes may be altered. In addition, data mining of T. gondii phosphoproteome and acetylome has allowed the generation of the phosphorylation and acetylation map of TgHsp90. This review focuses on the potential roles of TgHsp90 in parasite biology and the analysis of experimental data in comparison with its counterparts in yeast and humans.Fil: Ángel, Sergio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Figueras López, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Alomar, María Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Echeverria, Pablo Christian. Universidad de Ginebra; SuizaFil: Deng, Bin. The University of Vermont; Estados UnidosCambridge University Press2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24700Ángel, Sergio Oscar; Figueras López, María Julia; Alomar, María Lis; Echeverria, Pablo Christian; Deng, Bin; Toxoplasma gondii HSP90: potential roles in essential cellular processes of the parasite; Cambridge University Press; Parasitology; 141; 9; 1-2014; 1138-11470031-1820CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1017/S0031182014000055info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/parasitology/article/toxoplasma-gondii-hsp90-potential-roles-in-essential-cellular-processes-of-the-parasite/FEA49F3900F342B278F70683F7A43CB9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:28:42Zoai:ri.conicet.gov.ar:11336/24700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:28:42.369CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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