Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness

Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than that of isoform B (PR-B) and that they might stimulate growth when PR-B is pre...

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Authors: Rojas, Paola Andrea, May, Maria, Sequeira, Gonzalo Ricardo, Elia, Andres Maximiliano, Alvarez, Michelle, Martínez, Paula, González, Pedro, Hewitt, Stephen, He, Xiaping, Perou, Charles M., Molinolo, Alfredo, Gibbons, Luz, Abba, Martín Carlos, Gass, Hugo, Lanari, Claudia Lee Malvina
Format: article
Status:Published version
Publication Date:2017
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/24588
Online Access:http://hdl.handle.net/11336/24588
Access Level:Open access
Keyword:Receptor de Progesterona
Antiprogestageno
Cancer de Mama
Isoforma A
Breast Neoplasms
Progestins
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24588
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
title Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
spellingShingle Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
Rojas, Paola Andrea
Receptor de Progesterona
Antiprogestageno
Cancer de Mama
Isoforma A
Breast Neoplasms
Progestins
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
title_full Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
title_fullStr Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
title_full_unstemmed Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
title_sort Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
dc.creator.none.fl_str_mv Rojas, Paola Andrea
May, Maria
Sequeira, Gonzalo Ricardo
Elia, Andres Maximiliano
Alvarez, Michelle
Martínez, Paula
González, Pedro
Hewitt, Stephen
He, Xiaping
Perou, Charles M.
Molinolo, Alfredo
Gibbons, Luz
Abba, Martín Carlos
Gass, Hugo
Lanari, Claudia Lee Malvina
author Rojas, Paola Andrea
author_facet Rojas, Paola Andrea
May, Maria
Sequeira, Gonzalo Ricardo
Elia, Andres Maximiliano
Alvarez, Michelle
Martínez, Paula
González, Pedro
Hewitt, Stephen
He, Xiaping
Perou, Charles M.
Molinolo, Alfredo
Gibbons, Luz
Abba, Martín Carlos
Gass, Hugo
Lanari, Claudia Lee Malvina
author_role author
author2 May, Maria
Sequeira, Gonzalo Ricardo
Elia, Andres Maximiliano
Alvarez, Michelle
Martínez, Paula
González, Pedro
Hewitt, Stephen
He, Xiaping
Perou, Charles M.
Molinolo, Alfredo
Gibbons, Luz
Abba, Martín Carlos
Gass, Hugo
Lanari, Claudia Lee Malvina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Receptor de Progesterona
Antiprogestageno
Cancer de Mama
Isoforma A
Breast Neoplasms
Progestins
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Receptor de Progesterona
Antiprogestageno
Cancer de Mama
Isoforma A
Breast Neoplasms
Progestins
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than that of isoform B (PR-B) and that they might stimulate growth when PR-B is predominant. The aims of this study were to investigate ex vivo responses to mifepristone (MFP) in breast carcinomas with different PR isoform ratios and to examine their clinical and molecular characteristics.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24588
Rojas, Paola Andrea; May, Maria; Sequeira, Gonzalo Ricardo; Elia, Andres Maximiliano; Alvarez, Michelle; et al.; Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 109; 7; 7-2017; 1-9
0027-8874
1460-2105
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24588
identifier_str_mv Rojas, Paola Andrea; May, Maria; Sequeira, Gonzalo Ricardo; Elia, Andres Maximiliano; Alvarez, Michelle; et al.; Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 109; 7; 7-2017; 1-9
0027-8874
1460-2105
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jnci/article-abstract/109/7/djw317/3064537/Progesterone-Receptor-Isoform-Ratio-A-Breast?redirectedFrom=fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1093/jnci/djw317
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford Univ Press Inc
publisher.none.fl_str_mv Oxford Univ Press Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196395456954368
spelling Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsivenessRojas, Paola AndreaMay, MariaSequeira, Gonzalo RicardoElia, Andres MaximilianoAlvarez, MichelleMartínez, PaulaGonzález, PedroHewitt, StephenHe, XiapingPerou, Charles M.Molinolo, AlfredoGibbons, LuzAbba, Martín CarlosGass, HugoLanari, Claudia Lee MalvinaReceptor de ProgesteronaAntiprogestagenoCancer de MamaIsoforma ABreast NeoplasmsProgestinshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than that of isoform B (PR-B) and that they might stimulate growth when PR-B is predominant. The aims of this study were to investigate ex vivo responses to mifepristone (MFP) in breast carcinomas with different PR isoform ratios and to examine their clinical and molecular characteristics.Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Elia, Andres Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Alvarez, Michelle. Provincia de Buenos Aires. Hospital Zonal General de Agudos Magdalena Villegas de Martínez; ArgentinaFil: Martínez, Paula. Provincia de Buenos Aires. Hospital Zonal General de Agudos Magdalena Villegas de Martínez; ArgentinaFil: González, Pedro. Provincia de Buenos Aires. Hospital Zonal General de Agudos Magdalena Villegas de Martínez; ArgentinaFil: Hewitt, Stephen. National Institutes of Health; Estados UnidosFil: He, Xiaping. University of North Carolina; Estados UnidosFil: Perou, Charles M.. University of North Carolina; Estados UnidosFil: Molinolo, Alfredo. University of California at San Diego; Estados UnidosFil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Gass, Hugo. Provincia de Buenos Aires. Hospital Zonal General de Agudos Magdalena Villegas de Martínez; ArgentinaFil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaOxford Univ Press Inc2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24588Rojas, Paola Andrea; May, Maria; Sequeira, Gonzalo Ricardo; Elia, Andres Maximiliano; Alvarez, Michelle; et al.; Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 109; 7; 7-2017; 1-90027-88741460-2105CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jnci/article-abstract/109/7/djw317/3064537/Progesterone-Receptor-Isoform-Ratio-A-Breast?redirectedFrom=fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1093/jnci/djw317info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:26:03Zoai:ri.conicet.gov.ar:11336/24588instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:26:04.09CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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