Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats

To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly und...

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Detalhes bibliográficos
Autores: Cardinali, Daniel Pedro, Scacchi Bernasconi, Pablo Antonio, Reynoso, Roxana María, Reyes Toso, Carlos Felipe, Scacchi, Pablo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/22114
Acesso em linha:http://hdl.handle.net/11336/22114
Access Level:acceso abierto
Palavra-chave:METABOLIC SYNDROME
MELATONIN
FRUCTOSE
DYSLIPIDEMIA
HYPERTENSION
OBESITY
GLUCOSE TOLERANCE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22114
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
title Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
spellingShingle Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
Cardinali, Daniel Pedro
METABOLIC SYNDROME
MELATONIN
FRUCTOSE
DYSLIPIDEMIA
HYPERTENSION
OBESITY
GLUCOSE TOLERANCE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
title_full Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
title_fullStr Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
title_full_unstemmed Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
title_sort Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo Antonio
Reynoso, Roxana María
Reyes Toso, Carlos Felipe
Scacchi, Pablo
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo Antonio
Reynoso, Roxana María
Reyes Toso, Carlos Felipe
Scacchi, Pablo
author_role author
author2 Scacchi Bernasconi, Pablo Antonio
Reynoso, Roxana María
Reyes Toso, Carlos Felipe
Scacchi, Pablo
author2_role author
author
author
author
dc.subject.none.fl_str_mv METABOLIC SYNDROME
MELATONIN
FRUCTOSE
DYSLIPIDEMIA
HYPERTENSION
OBESITY
GLUCOSE TOLERANCE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic METABOLIC SYNDROME
MELATONIN
FRUCTOSE
DYSLIPIDEMIA
HYPERTENSION
OBESITY
GLUCOSE TOLERANCE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22114
Cardinali, Daniel Pedro; Scacchi Bernasconi, Pablo Antonio; Reynoso, Roxana María; Reyes Toso, Carlos Felipe; Scacchi, Pablo; Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 14; 2; 1-2013; 2502-2514
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22114
identifier_str_mv Cardinali, Daniel Pedro; Scacchi Bernasconi, Pablo Antonio; Reynoso, Roxana María; Reyes Toso, Carlos Felipe; Scacchi, Pablo; Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 14; 2; 1-2013; 2502-2514
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1422-0067/14/2/2502
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms14022502
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195217476190208
spelling Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in ratsCardinali, Daniel PedroScacchi Bernasconi, Pablo AntonioReynoso, Roxana MaríaReyes Toso, Carlos FelipeScacchi, PabloMETABOLIC SYNDROMEMELATONINFRUCTOSEDYSLIPIDEMIAHYPERTENSIONOBESITYGLUCOSE TOLERANCEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases.Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Scacchi Bernasconi, Pablo Antonio. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reynoso, Roxana María. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reyes Toso, Carlos Felipe. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Scacchi, Pablo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMolecular Diversity Preservation International2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22114Cardinali, Daniel Pedro; Scacchi Bernasconi, Pablo Antonio; Reynoso, Roxana María; Reyes Toso, Carlos Felipe; Scacchi, Pablo; Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 14; 2; 1-2013; 2502-25141422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1422-0067/14/2/2502info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms14022502info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:46:24Zoai:ri.conicet.gov.ar:11336/22114instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:46:24.799CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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