Syntheses of immunomodulating androstanes and stigmastanes. Comparison of their TNF-alpha inhibitory activity
In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory act...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2007 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/71093 |
| Acceso en línea: | http://hdl.handle.net/11336/71093 |
| Access Level: | acceso abierto |
| Palabra clave: | ANDROSTANE DHEA IMMUNE REGULATION STEROIDS STIGMASTANE TUMOR NECROSIS FACTOR-Α https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-α production by macrophages. A preliminary qualitative structure-activity relationship was established. © 2007 Elsevier Ltd. All rights reserved. |
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