HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator...

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Detalles Bibliográficos
Autores: Cambiagno, Damián Alejandro, Giudicatti, Axel Joel, Arce, Agustín Lucas, Gagliardi, Delfina, Li, Lei, Yuan, Wei, Lundberg, Derek S., Weigel, Detlef, Manavella, Pablo Andrés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/145316
Acceso en línea:http://hdl.handle.net/11336/145316
Access Level:acceso abierto
Palabra clave:GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descripción
Sumario:HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.

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