Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleo...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2004 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/85359 |
| Acceso en línea: | http://hdl.handle.net/11336/85359 |
| Access Level: | acceso abierto |
| Palabra clave: | CANCER CDK CYCLIN-DEPENDENT KINASE GLYCOGEN SYNTHASE KINASE GLYCOGEN SYNTHASE KINASE-3 GSK-3 KINASE INHIBITOR MEM MERIDIANIN MODIFIED EAGLE MEDIUM MTT NEURODEGENERATIVE DISEASES PROTEIN KINASE https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| Sumario: | Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. |
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