Contribution of non-circadian neurons to the temporal organization of locomotor activity

In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has...

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Autores: Pírez, Nicolas, Bernabei Cornejo, Sofia Gala, Fernández Acosta, Magdalena, Duhart, José Manuel, Ceriani, Maria Fernanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/123448
Acceso en línea:http://hdl.handle.net/11336/123448
Access Level:acceso abierto
Palabra clave:CONNECTIVITY
DROSOPHILA
LOCOMOTOR RHYTHMS
NON-CIRCADIAN NEURONS
SLNVS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_68b79ecd783ef8a07aea438e6e6354b0
oai_identifier_str oai:ri.conicet.gov.ar:11336/123448
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Contribution of non-circadian neurons to the temporal organization of locomotor activity
title Contribution of non-circadian neurons to the temporal organization of locomotor activity
spellingShingle Contribution of non-circadian neurons to the temporal organization of locomotor activity
Pírez, Nicolas
CONNECTIVITY
DROSOPHILA
LOCOMOTOR RHYTHMS
NON-CIRCADIAN NEURONS
SLNVS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Contribution of non-circadian neurons to the temporal organization of locomotor activity
title_full Contribution of non-circadian neurons to the temporal organization of locomotor activity
title_fullStr Contribution of non-circadian neurons to the temporal organization of locomotor activity
title_full_unstemmed Contribution of non-circadian neurons to the temporal organization of locomotor activity
title_sort Contribution of non-circadian neurons to the temporal organization of locomotor activity
dc.creator.none.fl_str_mv Pírez, Nicolas
Bernabei Cornejo, Sofia Gala
Fernández Acosta, Magdalena
Duhart, José Manuel
Ceriani, Maria Fernanda
author Pírez, Nicolas
author_facet Pírez, Nicolas
Bernabei Cornejo, Sofia Gala
Fernández Acosta, Magdalena
Duhart, José Manuel
Ceriani, Maria Fernanda
author_role author
author2 Bernabei Cornejo, Sofia Gala
Fernández Acosta, Magdalena
Duhart, José Manuel
Ceriani, Maria Fernanda
author2_role author
author
author
author
dc.subject.none.fl_str_mv CONNECTIVITY
DROSOPHILA
LOCOMOTOR RHYTHMS
NON-CIRCADIAN NEURONS
SLNVS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic CONNECTIVITY
DROSOPHILA
LOCOMOTOR RHYTHMS
NON-CIRCADIAN NEURONS
SLNVS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on their axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times throughout the day, as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role in the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity in D. melanogaster.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123448
Pírez, Nicolas; Bernabei Cornejo, Sofia Gala; Fernández Acosta, Magdalena; Duhart, José Manuel; Ceriani, Maria Fernanda; Contribution of non-circadian neurons to the temporal organization of locomotor activity; Company of Biologists; Biology Open; 8; 1; 1-2019; 1-13
2046-6390
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123448
identifier_str_mv Pírez, Nicolas; Bernabei Cornejo, Sofia Gala; Fernández Acosta, Magdalena; Duhart, José Manuel; Ceriani, Maria Fernanda; Contribution of non-circadian neurons to the temporal organization of locomotor activity; Company of Biologists; Biology Open; 8; 1; 1-2019; 1-13
2046-6390
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1242/bio.039628
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195738028113920
spelling Contribution of non-circadian neurons to the temporal organization of locomotor activityPírez, NicolasBernabei Cornejo, Sofia GalaFernández Acosta, MagdalenaDuhart, José ManuelCeriani, Maria FernandaCONNECTIVITYDROSOPHILALOCOMOTOR RHYTHMSNON-CIRCADIAN NEURONSSLNVShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on their axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times throughout the day, as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role in the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity in D. melanogaster.Fil: Pírez, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Bernabei Cornejo, Sofia Gala. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández Acosta, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Duhart, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaCompany of Biologists2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123448Pírez, Nicolas; Bernabei Cornejo, Sofia Gala; Fernández Acosta, Magdalena; Duhart, José Manuel; Ceriani, Maria Fernanda; Contribution of non-circadian neurons to the temporal organization of locomotor activity; Company of Biologists; Biology Open; 8; 1; 1-2019; 1-132046-6390CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1242/bio.039628info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:02:00Zoai:ri.conicet.gov.ar:11336/123448instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:02:01.104CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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