Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
I read with great interest the elegant work by Mochizuki et al. ( 1 ) providing novel experimental evidence for the crucial role of von Willebrand factor (VWF), a prominent plasma protein associated with blood coagulation, in resistance to metastasis. The authors found that aggressive human breast a...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/198765 |
| Acceso en línea: | http://hdl.handle.net/11336/198765 |
| Access Level: | acceso abierto |
| Palabra clave: | Metastasis Von Willebrand factor Desmopressin Treatment https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| Sumario: | I read with great interest the elegant work by Mochizuki et al. ( 1 ) providing novel experimental evidence for the crucial role of von Willebrand factor (VWF), a prominent plasma protein associated with blood coagulation, in resistance to metastasis. The authors found that aggressive human breast and non-small cell lung carcinoma cells expressing high levels of ADAM28 are able to avoid VWF-induced apoptosis at metastatic sites. ADAM28 binds and cleaves VWF, thus enhancing metastasis by favoring cancer cell survival within the blood vessels. I completely agree with the authors in the sense that ADAM28 can be a potential molecular target for cancer therapy, and the development of selective inhibitors of the proteinase is expected. However, another strategy could be to raise the levels of VWF by a pharmacological intervention to stimulate a natural defense against metastasis formation. |
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