Interoception primes emotional processing: multimodal evidence from neurodegeneration

Salamone, Paula Celeste; Legaz, Agustina; Sedeño, Lucas; Moguilner, Sebastian Gabriel; Fraile Vázquez, Matías; Gonzalez Campo, Cecilia; Fittipaldi, María Sol; Yoris, Adrián Isidro; Miranda, Magdalena; Birba, Agustina; Galiani, Agustina; Abrevaya, Sofia; Neely, Alejandra; Martorell Caro, Miguel Angel; Alifano Ferrero, Florencia; Villagra, Roque; Anunziata, Florencia; Oliveira, Maira Okada de; Pautassi, Ricardo Marcos; Slachevsky, Andrea; Serrano, Cecilia Mariela; García, Adolfo Martín; Ibáñez, Santiago Agustín

Interoception primes emotional processing: multimodal evidence from neurodegeneration

Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegener...

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Authors:	Salamone, Paula Celeste, Legaz, Agustina, Sedeño, Lucas, Moguilner, Sebastian Gabriel, Fraile Vázquez, Matías, Gonzalez Campo, Cecilia, Fittipaldi, María Sol, Yoris, Adrián Isidro, Miranda, Magdalena, Birba, Agustina, Galiani, Agustina, Abrevaya, Sofia, Neely, Alejandra, Martorell Caro, Miguel Angel, Alifano Ferrero, Florencia, Villagra, Roque, Anunziata, Florencia, Oliveira, Maira Okada de, Pautassi, Ricardo Marcos, Slachevsky, Andrea, Serrano, Cecilia Mariela, García, Adolfo Martín, Ibáñez, Santiago Agustín
Format:	article
Status:	Published version
Publication Date:	2021
Country:	Argentina
Institution:	Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:	CONICET Digital (CONICET)
Language:	English
OAI Identifier:	oai:ri.conicet.gov.ar:11336/166574
Online Access:	http://hdl.handle.net/11336/166574
Access Level:	Open access
Keyword:	ALZHEIMER'S DISEASE BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA EMOTION INTEROCEPTION PARKINSON'S DISEASE PRIMING https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5

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oai_identifier_str	oai:ri.conicet.gov.ar:11336/166574
network_acronym_str	AR
network_name_str	Argentina
repository_id_str
dc.title.none.fl_str_mv	Interoception primes emotional processing: multimodal evidence from neurodegeneration
title	Interoception primes emotional processing: multimodal evidence from neurodegeneration
spellingShingle	Interoception primes emotional processing: multimodal evidence from neurodegeneration Salamone, Paula Celeste ALZHEIMER'S DISEASE BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA EMOTION INTEROCEPTION PARKINSON'S DISEASE PRIMING https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5
title_short	Interoception primes emotional processing: multimodal evidence from neurodegeneration
title_full	Interoception primes emotional processing: multimodal evidence from neurodegeneration
title_fullStr	Interoception primes emotional processing: multimodal evidence from neurodegeneration
title_full_unstemmed	Interoception primes emotional processing: multimodal evidence from neurodegeneration
title_sort	Interoception primes emotional processing: multimodal evidence from neurodegeneration
dc.creator.none.fl_str_mv	Salamone, Paula Celeste Legaz, Agustina Sedeño, Lucas Moguilner, Sebastian Gabriel Fraile Vázquez, Matías Gonzalez Campo, Cecilia Fittipaldi, María Sol Yoris, Adrián Isidro Miranda, Magdalena Birba, Agustina Galiani, Agustina Abrevaya, Sofia Neely, Alejandra Martorell Caro, Miguel Angel Alifano Ferrero, Florencia Villagra, Roque Anunziata, Florencia Oliveira, Maira Okada de Pautassi, Ricardo Marcos Slachevsky, Andrea Serrano, Cecilia Mariela García, Adolfo Martín Ibáñez, Santiago Agustín
author	Salamone, Paula Celeste
author_facet	Salamone, Paula Celeste Legaz, Agustina Sedeño, Lucas Moguilner, Sebastian Gabriel Fraile Vázquez, Matías Gonzalez Campo, Cecilia Fittipaldi, María Sol Yoris, Adrián Isidro Miranda, Magdalena Birba, Agustina Galiani, Agustina Abrevaya, Sofia Neely, Alejandra Martorell Caro, Miguel Angel Alifano Ferrero, Florencia Villagra, Roque Anunziata, Florencia Oliveira, Maira Okada de Pautassi, Ricardo Marcos Slachevsky, Andrea Serrano, Cecilia Mariela García, Adolfo Martín Ibáñez, Santiago Agustín
author_role	author
author2	Legaz, Agustina Sedeño, Lucas Moguilner, Sebastian Gabriel Fraile Vázquez, Matías Gonzalez Campo, Cecilia Fittipaldi, María Sol Yoris, Adrián Isidro Miranda, Magdalena Birba, Agustina Galiani, Agustina Abrevaya, Sofia Neely, Alejandra Martorell Caro, Miguel Angel Alifano Ferrero, Florencia Villagra, Roque Anunziata, Florencia Oliveira, Maira Okada de Pautassi, Ricardo Marcos Slachevsky, Andrea Serrano, Cecilia Mariela García, Adolfo Martín Ibáñez, Santiago Agustín
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	ALZHEIMER'S DISEASE BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA EMOTION INTEROCEPTION PARKINSON'S DISEASE PRIMING https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5
topic	ALZHEIMER'S DISEASE BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA EMOTION INTEROCEPTION PARKINSON'S DISEASE PRIMING https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5
description	Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of nteroception, emotion, allostasis, and neurodegeneration.
publishDate	2021
dc.date.none.fl_str_mv	2021-05
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/166574 Salamone, Paula Celeste; Legaz, Agustina; Sedeño, Lucas; Moguilner, Sebastian Gabriel; Fraile Vázquez, Matías; et al.; Interoception primes emotional processing: multimodal evidence from neurodegeneration; Society for Neuroscience; Journal of Neuroscience; 41; 19; 5-2021; 4276-4292 0270-6474 CONICET Digital CONICET
url	http://hdl.handle.net/11336/166574
identifier_str_mv	Salamone, Paula Celeste; Legaz, Agustina; Sedeño, Lucas; Moguilner, Sebastian Gabriel; Fraile Vázquez, Matías; et al.; Interoception primes emotional processing: multimodal evidence from neurodegeneration; Society for Neuroscience; Journal of Neuroscience; 41; 19; 5-2021; 4276-4292 0270-6474 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/41/19/4276?fbclid=IwAR34ckA15T_gWhpb1mVm4XjlIyLGgoyOBVKs8CEBKTutoxAUflYxVsKO0rc info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.2578-20.2021
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Society for Neuroscience
publisher.none.fl_str_mv	Society for Neuroscience
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_	1799195188158005248
spelling	Interoception primes emotional processing: multimodal evidence from neurodegenerationSalamone, Paula CelesteLegaz, AgustinaSedeño, LucasMoguilner, Sebastian GabrielFraile Vázquez, MatíasGonzalez Campo, CeciliaFittipaldi, María SolYoris, Adrián IsidroMiranda, MagdalenaBirba, AgustinaGaliani, AgustinaAbrevaya, SofiaNeely, AlejandraMartorell Caro, Miguel AngelAlifano Ferrero, FlorenciaVillagra, RoqueAnunziata, FlorenciaOliveira, Maira Okada dePautassi, Ricardo MarcosSlachevsky, AndreaSerrano, Cecilia MarielaGarcía, Adolfo MartínIbáñez, Santiago AgustínALZHEIMER'S DISEASEBEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIAEMOTIONINTEROCEPTIONPARKINSON'S DISEASEPRIMINGhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of nteroception, emotion, allostasis, and neurodegeneration.Fil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad de San Andrés; ArgentinaFil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad de San Andrés; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos. Trinity College; Irlanda. Fundación Escuela de Medicina Nuclear; ArgentinaFil: Fraile Vázquez, Matías. Universidad de San Andrés; ArgentinaFil: Gonzalez Campo, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Fittipaldi, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Miranda, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Galiani, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Neely, Alejandra. Universidad Adolfo Ibañez; ChileFil: Martorell Caro, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Alifano Ferrero, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Villagra, Roque. Universidad de Chile; ChileFil: Anunziata, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Oliveira, Maira Okada de. University of California; Estados Unidos. Universidade de Sao Paulo; Brasil. Hospital Santa Marcelina; BrasilFil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Slachevsky, Andrea. Universidad de Chile.; Chile. Gerosciences Center for Brain Health and Metabolism; Chile. Universidad del Desarrollo; ChileFil: Serrano, Cecilia Mariela. Unidad Asistencial "Dr. César Milstein"; ArgentinaFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Trinity College; Irlanda. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Universidad de Santiago de Chile; ChileFil: Ibáñez, Santiago Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Trinity College; Irlanda. Universidad Adolfo Ibañez; ChileSociety for Neuroscience2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/166574Salamone, Paula Celeste; Legaz, Agustina; Sedeño, Lucas; Moguilner, Sebastian Gabriel; Fraile Vázquez, Matías; et al.; Interoception primes emotional processing: multimodal evidence from neurodegeneration; Society for Neuroscience; Journal of Neuroscience; 41; 19; 5-2021; 4276-42920270-6474CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/41/19/4276?fbclid=IwAR34ckA15T_gWhpb1mVm4XjlIyLGgoyOBVKs8CEBKTutoxAUflYxVsKO0rcinfo:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.2578-20.2021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:45:42Zoai:ri.conicet.gov.ar:11336/166574instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:45:42.788CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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Interoception primes emotional processing: multimodal evidence from neurodegeneration

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