Rat Brain Damage due to Iron and Copper Toxicity

Brain damage is associated to oxidative stress in iron (Fe) and copper (Cu) overloads in rats, in a dose- and time-dependent accumulation of the metals in the organ. The generation of singlet oxygen in brain measured in vivo by in situ chemiluminescence indicates that Fe and Cu overloads increased p...

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Detalles Bibliográficos
Autores: Musacco Sebio, Rosario Natalia, Saporito Magriñá, Christian Martín, Ferrarotti, Nidia Fatima, Acosta, Juan Manuel, Boveris, Alberto Antonio, Repetto, Marisa Gabriela
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/156369
Acceso en línea:http://hdl.handle.net/11336/156369
Access Level:acceso abierto
Palabra clave:BRAIN
IRON
COPPER
OXIDATIVE STRESS
TRANSITION METALS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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repository_id_str
spelling Rat Brain Damage due to Iron and Copper ToxicityMusacco Sebio, Rosario NataliaSaporito Magriñá, Christian MartínFerrarotti, Nidia FatimaAcosta, Juan ManuelBoveris, Alberto AntonioRepetto, Marisa GabrielaBRAINIRONCOPPEROXIDATIVE STRESSTRANSITION METALShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Brain damage is associated to oxidative stress in iron (Fe) and copper (Cu) overloads in rats, in a dose- and time-dependent accumulation of the metals in the organ. The generation of singlet oxygen in brain measured in vivo by in situ chemiluminescence indicates that Fe and Cu overloads increased phospholipid and protein oxidation, and decreased non enzymetic endogenous antioxidants content in the organ, mainly glutathione (GSH). These results fit with a Fenton/ Haber-Weiss type reaction between iron, copper and endogenously produced superoxide anion (O2 •-) and hydrogen peroxide (H2 O2 ) to yield hydroxyl radical (OH•), as well as reactions involving thiol groups of GSH and proteins.Fil: Musacco Sebio, Rosario Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Saporito Magriñá, Christian Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Ferrarotti, Nidia Fatima. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Acosta, Juan Manuel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Repetto, Marisa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaAustin Publications2017-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156369Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Ferrarotti, Nidia Fatima; Acosta, Juan Manuel; Boveris, Alberto Antonio; et al.; Rat Brain Damage due to Iron and Copper Toxicity; Austin Publications; Austin Journal of Neurological Disorders & Epilepsy; 4; 1; 6-2017; 1-42472-3711CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:12:44Zoai:ri.conicet.gov.ar:11336/156369instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:12:44.926CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rat Brain Damage due to Iron and Copper Toxicity
title Rat Brain Damage due to Iron and Copper Toxicity
spellingShingle Rat Brain Damage due to Iron and Copper Toxicity
Musacco Sebio, Rosario Natalia
BRAIN
IRON
COPPER
OXIDATIVE STRESS
TRANSITION METALS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Rat Brain Damage due to Iron and Copper Toxicity
title_full Rat Brain Damage due to Iron and Copper Toxicity
title_fullStr Rat Brain Damage due to Iron and Copper Toxicity
title_full_unstemmed Rat Brain Damage due to Iron and Copper Toxicity
title_sort Rat Brain Damage due to Iron and Copper Toxicity
dc.creator.none.fl_str_mv Musacco Sebio, Rosario Natalia
Saporito Magriñá, Christian Martín
Ferrarotti, Nidia Fatima
Acosta, Juan Manuel
Boveris, Alberto Antonio
Repetto, Marisa Gabriela
author Musacco Sebio, Rosario Natalia
author_facet Musacco Sebio, Rosario Natalia
Saporito Magriñá, Christian Martín
Ferrarotti, Nidia Fatima
Acosta, Juan Manuel
Boveris, Alberto Antonio
Repetto, Marisa Gabriela
author_role author
author2 Saporito Magriñá, Christian Martín
Ferrarotti, Nidia Fatima
Acosta, Juan Manuel
Boveris, Alberto Antonio
Repetto, Marisa Gabriela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN
IRON
COPPER
OXIDATIVE STRESS
TRANSITION METALS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic BRAIN
IRON
COPPER
OXIDATIVE STRESS
TRANSITION METALS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Brain damage is associated to oxidative stress in iron (Fe) and copper (Cu) overloads in rats, in a dose- and time-dependent accumulation of the metals in the organ. The generation of singlet oxygen in brain measured in vivo by in situ chemiluminescence indicates that Fe and Cu overloads increased phospholipid and protein oxidation, and decreased non enzymetic endogenous antioxidants content in the organ, mainly glutathione (GSH). These results fit with a Fenton/ Haber-Weiss type reaction between iron, copper and endogenously produced superoxide anion (O2 •-) and hydrogen peroxide (H2 O2 ) to yield hydroxyl radical (OH•), as well as reactions involving thiol groups of GSH and proteins.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156369
Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Ferrarotti, Nidia Fatima; Acosta, Juan Manuel; Boveris, Alberto Antonio; et al.; Rat Brain Damage due to Iron and Copper Toxicity; Austin Publications; Austin Journal of Neurological Disorders & Epilepsy; 4; 1; 6-2017; 1-4
2472-3711
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156369
identifier_str_mv Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Ferrarotti, Nidia Fatima; Acosta, Juan Manuel; Boveris, Alberto Antonio; et al.; Rat Brain Damage due to Iron and Copper Toxicity; Austin Publications; Austin Journal of Neurological Disorders & Epilepsy; 4; 1; 6-2017; 1-4
2472-3711
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Austin Publications
publisher.none.fl_str_mv Austin Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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