Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis
A growing body of evidence indicates that nonalcoholic fatty liver disease (NAFLD) develops from a complex process that includes genetic susceptibility and environmental exposure. Regardless of whether it is the cause or the consequence of the metabolic syndrome (MetS), NAFLD often co-occurs with on...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/49893 |
| Acceso en línea: | http://hdl.handle.net/11336/49893 |
| Access Level: | acceso abierto |
| Palabra clave: | Nafld Genetics Metabolic Syndrome Networks Twin Study https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.2 |
| Sumario: | A growing body of evidence indicates that nonalcoholic fatty liver disease (NAFLD) develops from a complex process that includes genetic susceptibility and environmental exposure. Regardless of whether it is the cause or the consequence of the metabolic syndrome (MetS), NAFLD often co-occurs with one or more MetS-associated phenotypes. There is also robust evidence in support of NAFLD and MetS sharing common pathogenic mechanisms.(1) Nevertheless, with the exception of the transmembrane 6 superfamily member 2 gene(2)— which illustrates an unexpected opposite association between NAFLD and cardiovascular disease, although it can be suspected—no compelling report demonstrating that NAFLD and MetS share a common genetic background presently exists. In this issue, Cui et al. show not only that steatosis and fibrosis potentially share the same predisposing genes but also that these conditions have a significant shared gene effect with metabolic risk factors,(3) the latter being a truly remarkable finding. These interesting results prompt several reflections. |
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