Phytotoxic Withanolides from Jaborosa rotacea
Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid δ-lactone (1-5); one contained a 26,12-δ-lactone and a C-12-C-23 bond (6); five corresponded to trechonolide-type withanolides with configuration at C-23 opposite of those previously isolated (7, 8,...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/32933 |
| Acceso en línea: | http://hdl.handle.net/11336/32933 |
| Access Level: | acceso abierto |
| Palabra clave: | Phytotoxic Withanolides Jaborosa Rotaceae https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid δ-lactone (1-5); one contained a 26,12-δ-lactone and a C-12-C-23 bond (6); five corresponded to trechonolide-type withanolides with configuration at C-23 opposite of those previously isolated (7, 8, 10-12); two of these have an additional oxido-bridge between C-21 and C-24; finally a withanolide with a hemiketal ring formed between a 21-hydroxyl and a 12-ketone (13) and the closely related jaborosalactone R were also isolated. New compounds were fully characterized by a combination of spectroscopic methods (1D and 2D NMR and MS). The structures of the spiranoid withanolide and of the epimer of trechonolide A were confirmed by X-ray diffraction studies. Compounds 4, 5, 6, and 8 showed selective phytotoxicity toward monocotyledoneous and dicotyledoneous species. |
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