Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice

Background: Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to pre...

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Autores: Beauquis, Juan, Roig, Paulina, de Nicola, Alejandro Federico, Saravia, Flavia Eugenia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/14672
Acceso en línea:http://hdl.handle.net/11336/14672
Access Level:acceso abierto
Palabra clave:TYPE 1 DIABETES
HIPPOCAMPUS
ENRICHED ENVIRONMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic miceBeauquis, JuanRoig, Paulinade Nicola, Alejandro FedericoSaravia, Flavia EugeniaTYPE 1 DIABETESHIPPOCAMPUSENRICHED ENVIRONMENThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes. Methodology/Principal Findings: We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals. Conclusions/Significance: The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression.Fil: Beauquis, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Roig, Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaPublic Library Of Science2010-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14672Beauquis, Juan; Roig, Paulina; de Nicola, Alejandro Federico; Saravia, Flavia Eugenia; Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice; Public Library Of Science; Plos One; 5; 11; 15-11-2010; e13993-e139991932-62031932-6203enginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013993info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1371/journal.pone.0013993info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981567/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:43:33Zoai:ri.conicet.gov.ar:11336/14672instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:43:33.599CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
title Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
spellingShingle Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
Beauquis, Juan
TYPE 1 DIABETES
HIPPOCAMPUS
ENRICHED ENVIRONMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
title_full Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
title_fullStr Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
title_full_unstemmed Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
title_sort Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice
dc.creator.none.fl_str_mv Beauquis, Juan
Roig, Paulina
de Nicola, Alejandro Federico
Saravia, Flavia Eugenia
author Beauquis, Juan
author_facet Beauquis, Juan
Roig, Paulina
de Nicola, Alejandro Federico
Saravia, Flavia Eugenia
author_role author
author2 Roig, Paulina
de Nicola, Alejandro Federico
Saravia, Flavia Eugenia
author2_role author
author
author
dc.subject.none.fl_str_mv TYPE 1 DIABETES
HIPPOCAMPUS
ENRICHED ENVIRONMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic TYPE 1 DIABETES
HIPPOCAMPUS
ENRICHED ENVIRONMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Background: Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes. Methodology/Principal Findings: We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals. Conclusions/Significance: The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression.
publishDate 2010
dc.date.none.fl_str_mv 2010-11-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14672
Beauquis, Juan; Roig, Paulina; de Nicola, Alejandro Federico; Saravia, Flavia Eugenia; Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice; Public Library Of Science; Plos One; 5; 11; 15-11-2010; e13993-e13999
1932-6203
1932-6203
url http://hdl.handle.net/11336/14672
identifier_str_mv Beauquis, Juan; Roig, Paulina; de Nicola, Alejandro Federico; Saravia, Flavia Eugenia; Short-term environmental enrichment increases adult neurogenesis and dendritic complexity in type 1 diabetic mice; Public Library Of Science; Plos One; 5; 11; 15-11-2010; e13993-e13999
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013993
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1371/journal.pone.0013993
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981567/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Of Science
publisher.none.fl_str_mv Public Library Of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.812429

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