Exploring Photooxidative Degradation Pathways of Harmol and Harmalol alkaloids in Water: Effects of pH, Excitation Sources and Atmospheric Conditions
This work explores the photochemical degradation of the cationic species of 7-hydroxy-1-methyl-2H-pyrido [3,4-b]indole or harmol (1C) and the corresponding partially hydrogenated derivative 7-hydroxy-1-methyl-3,4-dihydro-2H-pyrido [3,4-b]indole or harmalol (2C) in aqueous solution. UV–visible absorp...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/231276 |
| Acceso en línea: | http://hdl.handle.net/11336/231276 |
| Access Level: | acceso embargado |
| Palabra clave: | β-carbolines Photochemistry MCR-ALS PARAFAC https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | This work explores the photochemical degradation of the cationic species of 7-hydroxy-1-methyl-2H-pyrido [3,4-b]indole or harmol (1C) and the corresponding partially hydrogenated derivative 7-hydroxy-1-methyl-3,4-dihydro-2H-pyrido [3,4-b]indole or harmalol (2C) in aqueous solution. UV–visible absorption and fluorescence emission spectroscopy coupled with multivariate data analysis (MCR-ALS and PARAFAC), HPLC and HRESI-MS techniques were used for both quantitative and qualitative analysis. The formation of hydrogen peroxide reactive oxygen species (ROS) was quantified, and the influence of pH, oxygen partial pressure and photoexcitation source on the photochemical degradation of both compounds was assessed. The potential implications on the βCs biosynthesis and their biological role in living systems is discussed. |
|---|