Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral...

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Detalhes bibliográficos
Autores: Querido, Jailson F. B., Echeverria, Maria Gabriela, Marti, Gerardo Anibal, Medina Costa, Rita, Susevich, Maria Laura, Rabinovich, Jorge Eduardo, Copa, Aydee, Montaño, Nair A., García, Lineth, Cordova, Marisol, Torrico, Faustino, Sánchez Eugenia, Rubén, Sánchez Magraner, Lissete, Muñiz Trabudua, Xabier, López Marijuan, Ibai, Rozas Dennis, Gabriela S., Diosque, Patricio, de Castro, Ana M., Robello, Carlos, Rodríguez, Julio S., Altcheh, Jaime Marcelo, Salazar Schettino, Paz M., Bucio, Marta I., Espinoza, Bertha, Guérin, Diego M. A., Silva, Marcelo Sousa
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2015
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/10680
Acesso em linha:http://hdl.handle.net/11336/10680
Access Level:Acceso aberto
Palavra-chave:TRIATOMA VIRUS
DICISTROVIRIDAE
TRYPANOSOMA CRUZI
TRIATOMINES
CHAGAS DISEASE
MATHEMATICAL MODEL
BIOLOGICAL CONTROL
PASSIVE VIRAL EXPOSURE
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descrição
Resumo:Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.

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