Brain oscillations, medium spiny neurons, and dopamine

1. The striatum is part of a multisynaptic loop involved in translating higher order cognitive activity into action. The main striatal computational unit is the medium spiny neuron, which integrates inputs arriving from widely distributed cortical neurons and provides the sole striatal output. 2. Th...

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Detalles Bibliográficos
Autores: Murer, Mario Gustavo, Tseng, Kuei Y., Kasanetz, Fernando, Belluscio, Mariano Andres, Riquelme, Luis Alberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2002
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/163251
Acceso en línea:http://hdl.handle.net/11336/163251
Access Level:acceso abierto
Palabra clave:CEREBRAL CORTEX
EEG
IN VIVO INTRACELLULAR RECORDING
PARKINSON'S DISEASE
STRIATAL MEDIUM SPINY NEURON
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_4ed91efcd72fe2dde09dcd25c7508cff
oai_identifier_str oai:ri.conicet.gov.ar:11336/163251
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Brain oscillations, medium spiny neurons, and dopamine
title Brain oscillations, medium spiny neurons, and dopamine
spellingShingle Brain oscillations, medium spiny neurons, and dopamine
Murer, Mario Gustavo
CEREBRAL CORTEX
EEG
IN VIVO INTRACELLULAR RECORDING
PARKINSON'S DISEASE
STRIATAL MEDIUM SPINY NEURON
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Brain oscillations, medium spiny neurons, and dopamine
title_full Brain oscillations, medium spiny neurons, and dopamine
title_fullStr Brain oscillations, medium spiny neurons, and dopamine
title_full_unstemmed Brain oscillations, medium spiny neurons, and dopamine
title_sort Brain oscillations, medium spiny neurons, and dopamine
dc.creator.none.fl_str_mv Murer, Mario Gustavo
Tseng, Kuei Y.
Kasanetz, Fernando
Belluscio, Mariano Andres
Riquelme, Luis Alberto
author Murer, Mario Gustavo
author_facet Murer, Mario Gustavo
Tseng, Kuei Y.
Kasanetz, Fernando
Belluscio, Mariano Andres
Riquelme, Luis Alberto
author_role author
author2 Tseng, Kuei Y.
Kasanetz, Fernando
Belluscio, Mariano Andres
Riquelme, Luis Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv CEREBRAL CORTEX
EEG
IN VIVO INTRACELLULAR RECORDING
PARKINSON'S DISEASE
STRIATAL MEDIUM SPINY NEURON
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic CEREBRAL CORTEX
EEG
IN VIVO INTRACELLULAR RECORDING
PARKINSON'S DISEASE
STRIATAL MEDIUM SPINY NEURON
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description 1. The striatum is part of a multisynaptic loop involved in translating higher order cognitive activity into action. The main striatal computational unit is the medium spiny neuron, which integrates inputs arriving from widely distributed cortical neurons and provides the sole striatal output. 2. The membrane potential of medium spiny neurons’ displays shifts between a very negative resting state (down state) and depolarizing plateaus (up states) which are driven by the excitatory cortical inputs. 3. Because striatal spiny neurons fire action potentials only during the up state, these plateau depolarizations are perceived as enabling events that allow information processing through cerebral cortex – basal ganglia circuits. In vivo intracellular recording techniques allow to investigate simultaneously the subthreshold behavior of the medium spiny neuron membrane potential (which is a “reading” of distributed patterns of cortical activity) and medium spiny neuron firing (which is an index of striatal output). 4. Recent studies combining intracellular recordings of striatal neurons with field potential recordings of the cerebral cortex illustrate how the analysis of the input–output transformations performed by medium spiny neurons may help to unveil some aspects of information processing in cerebral cortex – basal ganglia circuits, and to understand the origin of the clinical manifestations of Parkinson’s disease and other neurologic and neuropsychiatric disorders that result from alterations in dopamine-dependent information processing in the cerebral cortex – basal ganglia circuits.
publishDate 2002
dc.date.none.fl_str_mv 2002-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163251
Murer, Mario Gustavo; Tseng, Kuei Y.; Kasanetz, Fernando; Belluscio, Mariano Andres; Riquelme, Luis Alberto; Brain oscillations, medium spiny neurons, and dopamine; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 22; 5-6; 12-2002; 611-632
0272-4340
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163251
identifier_str_mv Murer, Mario Gustavo; Tseng, Kuei Y.; Kasanetz, Fernando; Belluscio, Mariano Andres; Riquelme, Luis Alberto; Brain oscillations, medium spiny neurons, and dopamine; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 22; 5-6; 12-2002; 611-632
0272-4340
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1021840504342
info:eu-repo/semantics/altIdentifier/doi/10.1023/A:1021840504342
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer/Plenum Publishers
publisher.none.fl_str_mv Springer/Plenum Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Brain oscillations, medium spiny neurons, and dopamineMurer, Mario GustavoTseng, Kuei Y.Kasanetz, FernandoBelluscio, Mariano AndresRiquelme, Luis AlbertoCEREBRAL CORTEXEEGIN VIVO INTRACELLULAR RECORDINGPARKINSON'S DISEASESTRIATAL MEDIUM SPINY NEURONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/31. The striatum is part of a multisynaptic loop involved in translating higher order cognitive activity into action. The main striatal computational unit is the medium spiny neuron, which integrates inputs arriving from widely distributed cortical neurons and provides the sole striatal output. 2. The membrane potential of medium spiny neurons’ displays shifts between a very negative resting state (down state) and depolarizing plateaus (up states) which are driven by the excitatory cortical inputs. 3. Because striatal spiny neurons fire action potentials only during the up state, these plateau depolarizations are perceived as enabling events that allow information processing through cerebral cortex – basal ganglia circuits. In vivo intracellular recording techniques allow to investigate simultaneously the subthreshold behavior of the medium spiny neuron membrane potential (which is a “reading” of distributed patterns of cortical activity) and medium spiny neuron firing (which is an index of striatal output). 4. Recent studies combining intracellular recordings of striatal neurons with field potential recordings of the cerebral cortex illustrate how the analysis of the input–output transformations performed by medium spiny neurons may help to unveil some aspects of information processing in cerebral cortex – basal ganglia circuits, and to understand the origin of the clinical manifestations of Parkinson’s disease and other neurologic and neuropsychiatric disorders that result from alterations in dopamine-dependent information processing in the cerebral cortex – basal ganglia circuits.Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Tseng, Kuei Y.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Kasanetz, Fernando. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Belluscio, Mariano Andres. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Riquelme, Luis Alberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaSpringer/Plenum Publishers2002-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163251Murer, Mario Gustavo; Tseng, Kuei Y.; Kasanetz, Fernando; Belluscio, Mariano Andres; Riquelme, Luis Alberto; Brain oscillations, medium spiny neurons, and dopamine; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 22; 5-6; 12-2002; 611-6320272-4340CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1021840504342info:eu-repo/semantics/altIdentifier/doi/10.1023/A:1021840504342info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:22:34Zoai:ri.conicet.gov.ar:11336/163251instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:22:35.277CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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