High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

The range of vaccines developed against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) provides a unique opportunity to study immunization across different platforms. In a single-center cohort, we analyzed the humoral and cellular immune compartments following five coronavirus disease...

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Detalles Bibliográficos
Autores: Núñez, Nicolás, Schmid, Jonas, Power, Laura, Alberti, Chiara, Krishnarajah, Sinduya, Kreutmair, Stefanie, Unger, Susanne, Blanco, Sebastián Gabriel, Konigheim, Brenda Salome, Marin, Constanza, Onofrio, Luisina Inés, Kienzler, Jenny Christine, Costa Pereira, Sara, Ingelfinger, Florian, Cerban, Fabio Marcelo, Chiapello, Laura Silvina, Montes, Carolina Lucia, Motran, Claudia Cristina, Dutto, Jeremias, Almada, Laura, Boffelli, Lucía, Spinsanti, Lorena Ivana, Diaz, Luis Adrian, Rivarola, María Elisa, Aguilar, Javier, Beranek, Mauricio Daniel, Pasinovich, Marina E., Castelli, Juan Manuel, Vizzotti, Carla, Schaefer, Maximilian, Villar Vesga, Juan, Mundt, Sarah, Merten, Carla Helena, Sethi, Aakriti, Wertheimer, Tobias, Lutz, Mirjam, Vanoaica, Danusia, Sotomayor, Claudia Elena, Gruppi, Adriana, Münz, Christian, Cardozo, Diego, Barbás, Gabriela, López, Laura, Carreño, Paula, Castro, Gonzalo, Raboy, Elías Gabriel, Gallego, Sandra Veronica, Moron, Victor Gabriel, Cervi, Laura Alejandra, Acosta Rodriguez, Eva Virginia, Maletto, Belkys Angélica, Maccioni, Mariana, Becher, Burkhard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/233060
Acceso en línea:http://hdl.handle.net/11336/233060
Access Level:acceso abierto
Palabra clave:COVID-19
VACCINE
CELL-MEDIATED IMMUNITY
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
Descripción
Sumario:The range of vaccines developed against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) provides a unique opportunity to study immunization across different platforms. In a single-center cohort, we analyzed the humoral and cellular immune compartments following five coronavirus disease 2019 (COVID-19) vaccines spanning three technologies (adenoviral, mRNA and inactivated virus) administered in 16 combinations. For adenoviral and inactivated-virus vaccines, heterologous combinations were generally more immunogenic compared to homologous regimens. The mRNA vaccine as the second dose resulted in the strongest antibody response and induced the highest frequency of spike-binding memory B cells irrespective of the priming vaccine. Priming with the inactivated-virus vaccine increased the SARS-CoV-2-specific T cell response, whereas boosting did not. Distinct immune signatures were elicited by the different vaccine combinations, demonstrating that the immune response is shaped by the type of vaccines applied and the order in which they are delivered. These data provide a framework for improving future vaccine strategies against pathogens and cancer.

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