A role for the endogenous opioid β-endorphin in energy homeostasis

Proopiomelanocortin (POMC) neurons in the hypothalamus are direct targets of the adipostatic hormone leptin and contribute to energy homeostasis by integrating peripheral and central information. The melanocortin and β-endorphin neuropeptides are processed from POMC and putatively coreleased at axon...

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Detalles Bibliográficos
Autores: Appleyard, Suzanne M., Hayward, Michael, Young, Juan I., Butler, Andrew A., Cone, Roger D., Rubinstein, Marcelo, Low, Malcolm J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/79846
Acceso en línea:http://hdl.handle.net/11336/79846
Access Level:acceso abierto
Palabra clave:Endorfinas
Obesidad
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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spelling A role for the endogenous opioid β-endorphin in energy homeostasisAppleyard, Suzanne M.Hayward, MichaelYoung, Juan I.Butler, Andrew A.Cone, Roger D.Rubinstein, MarceloLow, Malcolm J.EndorfinasObesidadhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Proopiomelanocortin (POMC) neurons in the hypothalamus are direct targets of the adipostatic hormone leptin and contribute to energy homeostasis by integrating peripheral and central information. The melanocortin and β-endorphin neuropeptides are processed from POMC and putatively coreleased at axon terminals. Melanocortins have been shown by a combination of pharmacological and genetic methods to have inhibitory effects on appetite and body weight. In contrast, pharmacological studies have generally indicated that opioids stimulate food intake. Here we report that male mice engineered to selectively lack β-endorphin, but that retained normal melanocortin signaling, were hyperphagic and obese. Furthermore, β-endorphin mutant and wild-type mice had identical orexigenic responses to exogenous opioids and identical anorectic responses to the nonselective opioid antagonist naloxone, implicating an alternative endogenous opioid tone to β-endorphin that physiologically stimulates feeding. These genetic data indicate that β-endorphin is required for normal regulation of feeding, but, in contrast to earlier reports suggesting opposing actions of β-endorphin and melanocortins on appetite, our results suggest a more complementary interaction between the endogenously released POMC-derived peptides in the regulation of energy homeostasis.Fil: Appleyard, Suzanne M.. Oregon Health and Science University; Estados UnidosFil: Hayward, Michael. Oregon Health and Science University; Estados UnidosFil: Young, Juan I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Butler, Andrew A.. Oregon Health and Science University; Estados UnidosFil: Cone, Roger D.. Oregon Health and Science University; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Low, Malcolm J.. Oregon Health and Science University; Estados UnidosEndocrine Society2003-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79846Appleyard, Suzanne M.; Hayward, Michael; Young, Juan I.; Butler, Andrew A.; Cone, Roger D.; et al.; A role for the endogenous opioid β-endorphin in energy homeostasis; Endocrine Society; Endocrinology; 144; 5; 5-2003; 1753-17600013-7227CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1210/en.2002-221096info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/12697680info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/144/5/1753/2502026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:36:44Zoai:ri.conicet.gov.ar:11336/79846instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:36:44.98CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A role for the endogenous opioid β-endorphin in energy homeostasis
title A role for the endogenous opioid β-endorphin in energy homeostasis
spellingShingle A role for the endogenous opioid β-endorphin in energy homeostasis
Appleyard, Suzanne M.
Endorfinas
Obesidad
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short A role for the endogenous opioid β-endorphin in energy homeostasis
title_full A role for the endogenous opioid β-endorphin in energy homeostasis
title_fullStr A role for the endogenous opioid β-endorphin in energy homeostasis
title_full_unstemmed A role for the endogenous opioid β-endorphin in energy homeostasis
title_sort A role for the endogenous opioid β-endorphin in energy homeostasis
dc.creator.none.fl_str_mv Appleyard, Suzanne M.
Hayward, Michael
Young, Juan I.
Butler, Andrew A.
Cone, Roger D.
Rubinstein, Marcelo
Low, Malcolm J.
author Appleyard, Suzanne M.
author_facet Appleyard, Suzanne M.
Hayward, Michael
Young, Juan I.
Butler, Andrew A.
Cone, Roger D.
Rubinstein, Marcelo
Low, Malcolm J.
author_role author
author2 Hayward, Michael
Young, Juan I.
Butler, Andrew A.
Cone, Roger D.
Rubinstein, Marcelo
Low, Malcolm J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Endorfinas
Obesidad
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Endorfinas
Obesidad
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Proopiomelanocortin (POMC) neurons in the hypothalamus are direct targets of the adipostatic hormone leptin and contribute to energy homeostasis by integrating peripheral and central information. The melanocortin and β-endorphin neuropeptides are processed from POMC and putatively coreleased at axon terminals. Melanocortins have been shown by a combination of pharmacological and genetic methods to have inhibitory effects on appetite and body weight. In contrast, pharmacological studies have generally indicated that opioids stimulate food intake. Here we report that male mice engineered to selectively lack β-endorphin, but that retained normal melanocortin signaling, were hyperphagic and obese. Furthermore, β-endorphin mutant and wild-type mice had identical orexigenic responses to exogenous opioids and identical anorectic responses to the nonselective opioid antagonist naloxone, implicating an alternative endogenous opioid tone to β-endorphin that physiologically stimulates feeding. These genetic data indicate that β-endorphin is required for normal regulation of feeding, but, in contrast to earlier reports suggesting opposing actions of β-endorphin and melanocortins on appetite, our results suggest a more complementary interaction between the endogenously released POMC-derived peptides in the regulation of energy homeostasis.
publishDate 2003
dc.date.none.fl_str_mv 2003-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79846
Appleyard, Suzanne M.; Hayward, Michael; Young, Juan I.; Butler, Andrew A.; Cone, Roger D.; et al.; A role for the endogenous opioid β-endorphin in energy homeostasis; Endocrine Society; Endocrinology; 144; 5; 5-2003; 1753-1760
0013-7227
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79846
identifier_str_mv Appleyard, Suzanne M.; Hayward, Michael; Young, Juan I.; Butler, Andrew A.; Cone, Roger D.; et al.; A role for the endogenous opioid β-endorphin in energy homeostasis; Endocrine Society; Endocrinology; 144; 5; 5-2003; 1753-1760
0013-7227
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1210/en.2002-221096
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/12697680
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/144/5/1753/2502026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194800473243648
score 15,812455

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