Effect of melatonin on vascular reactivity in pancreatectomized rats

The present study was undertaken to assess whether the improvement of contractile performance of aortic rings by melatonin described in streptozotocin diabetic rats also occurs in another model of type I diabetes, the pancreatectomized rats. Adult male Wistar rats submitted to a subtotal pancreatect...

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Detalhes bibliográficos
Autores: Reyes Toso, Carlos Felipe, Linares, Laura M., Ricci, Conrado R., Aran, Martin, Pinto, Jorge E., Rodríguez, Ricardo Rosendo, Cardinali, Daniel Pedro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/43492
Acesso em linha:http://hdl.handle.net/11336/43492
Access Level:acceso abierto
Palavra-chave:Melatonin
Vascular
Reactivity
Pancreatectomy
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_4bd304c1ae514d54ff3ec2af9c04ea21
oai_identifier_str oai:ri.conicet.gov.ar:11336/43492
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network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Effect of melatonin on vascular reactivity in pancreatectomized rats
title Effect of melatonin on vascular reactivity in pancreatectomized rats
spellingShingle Effect of melatonin on vascular reactivity in pancreatectomized rats
Reyes Toso, Carlos Felipe
Melatonin
Vascular
Reactivity
Pancreatectomy
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Effect of melatonin on vascular reactivity in pancreatectomized rats
title_full Effect of melatonin on vascular reactivity in pancreatectomized rats
title_fullStr Effect of melatonin on vascular reactivity in pancreatectomized rats
title_full_unstemmed Effect of melatonin on vascular reactivity in pancreatectomized rats
title_sort Effect of melatonin on vascular reactivity in pancreatectomized rats
dc.creator.none.fl_str_mv Reyes Toso, Carlos Felipe
Linares, Laura M.
Ricci, Conrado R.
Aran, Martin
Pinto, Jorge E.
Rodríguez, Ricardo Rosendo
Cardinali, Daniel Pedro
author Reyes Toso, Carlos Felipe
author_facet Reyes Toso, Carlos Felipe
Linares, Laura M.
Ricci, Conrado R.
Aran, Martin
Pinto, Jorge E.
Rodríguez, Ricardo Rosendo
Cardinali, Daniel Pedro
author_role author
author2 Linares, Laura M.
Ricci, Conrado R.
Aran, Martin
Pinto, Jorge E.
Rodríguez, Ricardo Rosendo
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Melatonin
Vascular
Reactivity
Pancreatectomy
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Melatonin
Vascular
Reactivity
Pancreatectomy
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description The present study was undertaken to assess whether the improvement of contractile performance of aortic rings by melatonin described in streptozotocin diabetic rats also occurs in another model of type I diabetes, the pancreatectomized rats. Adult male Wistar rats submitted to a subtotal pancreatectomy and exhibiting altered levels of fasting glucose and an abnormal tolerance glucose test, were used. Sham-operated laparotomized rats were employed as controls. Dose-response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) and for phenylephrine-induced vasoconstriction were conducted. This protocol was repeated with rings pre-incubated in a high glucose solution (44 mmol/l). Pancreatectomy decreased significantly acetylcholine-induced relaxation of aortic rings, but not phenylephrine-induced vasoconstriction, the effect being amplified by preincubation in high glucose solution. The deleterious effect of a high glucose medium was more pronounced in pancreatectomized rats. Melatonin (10(-5) M) did not modify acetylcholine-induced relaxation in normal glucose concentration but was effective to prevent the impairment of relaxation brought about by exposure to high glucose solution. The contractile response to phenylephrine of aortic rings obtained from pancreatectomized rats was not affected by melatonin. The results further support the improvement by melatonin of endothelial-mediated relaxation in blood vessels of diabetic rats.
publishDate 2004
dc.date.none.fl_str_mv 2004-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43492
Reyes Toso, Carlos Felipe; Linares, Laura M.; Ricci, Conrado R.; Aran, Martin; Pinto, Jorge E.; et al.; Effect of melatonin on vascular reactivity in pancreatectomized rats; Elsevier; Life Sciences; 74; 25; 5-2004; 3085-3092
0024-3205
1879-0631
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43492
identifier_str_mv Reyes Toso, Carlos Felipe; Linares, Laura M.; Ricci, Conrado R.; Aran, Martin; Pinto, Jorge E.; et al.; Effect of melatonin on vascular reactivity in pancreatectomized rats; Elsevier; Life Sciences; 74; 25; 5-2004; 3085-3092
0024-3205
1879-0631
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0024320504001705
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2003.10.032
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196116641644544
spelling Effect of melatonin on vascular reactivity in pancreatectomized ratsReyes Toso, Carlos FelipeLinares, Laura M.Ricci, Conrado R.Aran, MartinPinto, Jorge E.Rodríguez, Ricardo RosendoCardinali, Daniel PedroMelatoninVascularReactivityPancreatectomyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The present study was undertaken to assess whether the improvement of contractile performance of aortic rings by melatonin described in streptozotocin diabetic rats also occurs in another model of type I diabetes, the pancreatectomized rats. Adult male Wistar rats submitted to a subtotal pancreatectomy and exhibiting altered levels of fasting glucose and an abnormal tolerance glucose test, were used. Sham-operated laparotomized rats were employed as controls. Dose-response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) and for phenylephrine-induced vasoconstriction were conducted. This protocol was repeated with rings pre-incubated in a high glucose solution (44 mmol/l). Pancreatectomy decreased significantly acetylcholine-induced relaxation of aortic rings, but not phenylephrine-induced vasoconstriction, the effect being amplified by preincubation in high glucose solution. The deleterious effect of a high glucose medium was more pronounced in pancreatectomized rats. Melatonin (10(-5) M) did not modify acetylcholine-induced relaxation in normal glucose concentration but was effective to prevent the impairment of relaxation brought about by exposure to high glucose solution. The contractile response to phenylephrine of aortic rings obtained from pancreatectomized rats was not affected by melatonin. The results further support the improvement by melatonin of endothelial-mediated relaxation in blood vessels of diabetic rats.Fil: Reyes Toso, Carlos Felipe. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaFil: Linares, Laura M.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaFil: Ricci, Conrado R.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaFil: Aran, Martin. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Pinto, Jorge E.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaFil: Rodríguez, Ricardo Rosendo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaFil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaElsevier2004-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43492Reyes Toso, Carlos Felipe; Linares, Laura M.; Ricci, Conrado R.; Aran, Martin; Pinto, Jorge E.; et al.; Effect of melatonin on vascular reactivity in pancreatectomized rats; Elsevier; Life Sciences; 74; 25; 5-2004; 3085-30920024-32051879-0631CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0024320504001705info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2003.10.032info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:15:22Zoai:ri.conicet.gov.ar:11336/43492instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:15:22.354CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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