Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle
Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase in the respiratory tract for up to 72 h postinfection, followed by hematogenous...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Argentina |
| Institución: | Instituto Nacional de Tecnología Agropecuaria |
| Repositorio: | INTA Digital (INTA) |
| Idioma: | inglés |
| OAI Identifier: | oai:localhost:20.500.12123/2535 |
| Acceso en línea: | http://jvi.asm.org/content/87/5/2489.long http://hdl.handle.net/20.500.12123/2535 http://dx.doi.org/10.1128/JVI.02879-12 |
| Access Level: | acceso abierto |
| Palabra clave: | Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Respuesta Inmunológica Sistema Respiratorio Cattle Animal Diseases Foot and Mouth Disease Immune Response Respiratory System |
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Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| title |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| spellingShingle |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle Pega, Juan Franco Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Respuesta Inmunológica Sistema Respiratorio Cattle Animal Diseases Foot and Mouth Disease Immune Response Respiratory System |
| title_short |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| title_full |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| title_fullStr |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| title_full_unstemmed |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| title_sort |
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle |
| dc.creator.none.fl_str_mv |
Pega, Juan Franco Bucafusco, Danilo Di Giacomo, Sebastián Schammas, Juan Manuel Malacari, Darío Amilcar Capozzo, Alejandra Victoria Arzt, J. Pérez-Beascoechea, C. Maradei, E. Rodríguez, L.L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author |
Pega, Juan Franco |
| author_facet |
Pega, Juan Franco Bucafusco, Danilo Di Giacomo, Sebastián Schammas, Juan Manuel Malacari, Darío Amilcar Capozzo, Alejandra Victoria Arzt, J. Pérez-Beascoechea, C. Maradei, E. Rodríguez, L.L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_role |
author |
| author2 |
Bucafusco, Danilo Di Giacomo, Sebastián Schammas, Juan Manuel Malacari, Darío Amilcar Capozzo, Alejandra Victoria Arzt, J. Pérez-Beascoechea, C. Maradei, E. Rodríguez, L.L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Respuesta Inmunológica Sistema Respiratorio Cattle Animal Diseases Foot and Mouth Disease Immune Response Respiratory System |
| topic |
Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Respuesta Inmunológica Sistema Respiratorio Cattle Animal Diseases Foot and Mouth Disease Immune Response Respiratory System |
| description |
Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase in the respiratory tract for up to 72 h postinfection, followed by hematogenous dissemination and vesicular lesions at oral and foot epithelia. The role of the early local adaptive immunity of the host in the outcome of the infection is not well understood. Here we report the kinetics of appearance of FMDV-specific antibody-secreting cells (ASC) in lymphoid organs along the respiratory tract and the spleen in cattle infected by aerosol exposure. While no responses were observed for up to 3 days postinfection (dpi), all animals developed FMDV-ASC in all the lymphoid organs studied at 4 dpi. Tracheobronchial lymph nodes were the most reactive organs at this time, and IgM was the predominant isotype, followed by IgG1. Numbers of FMDV-ASC were further augmented at 5 and 6 dpi, with an increasing prevalence in upper respiratory organs. Systemic antibody responses were slightly delayed compared with the local reaction. Also, IgM was the dominant isotype in serum at 5 dpi, coinciding with a sharp decrease of viral RNA detection in peripheral blood. These results indicate that following aerogenous administration, cattle develop a rapid and vigorous genuine local antibody response throughout the respiratory tract. Time course and isotype profiles indicate the presence of an efficient T cell-independent antibody response which drives the IgM-mediated virus clearance in cattle infected by FMDV aerosol exposure. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-03 2018-06-01T13:49:23Z 2018-06-01T13:49:23Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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http://jvi.asm.org/content/87/5/2489.long http://hdl.handle.net/20.500.12123/2535 0022-538X 1098-5514 http://dx.doi.org/10.1128/JVI.02879-12 |
| url |
http://jvi.asm.org/content/87/5/2489.long http://hdl.handle.net/20.500.12123/2535 http://dx.doi.org/10.1128/JVI.02879-12 |
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0022-538X 1098-5514 |
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eng |
| language |
eng |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf |
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Journal of Virology 87 (5) : 2489-2495. (March 2013) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
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Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) |
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INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
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tripaldi.nicolas@inta.gob.ar |
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Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected CattlePega, Juan FrancoBucafusco, DaniloDi Giacomo, SebastiánSchammas, Juan ManuelMalacari, Darío AmilcarCapozzo, Alejandra VictoriaArzt, J.Pérez-Beascoechea, C.Maradei, E.Rodríguez, L.L.Borca, Manuel VictorPerez Filgueira, Daniel MarianoGanado BovinoEnfermedades de los AnimalesFiebre AftosaRespuesta InmunológicaSistema RespiratorioCattleAnimal DiseasesFoot and Mouth DiseaseImmune ResponseRespiratory SystemFoot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase in the respiratory tract for up to 72 h postinfection, followed by hematogenous dissemination and vesicular lesions at oral and foot epithelia. The role of the early local adaptive immunity of the host in the outcome of the infection is not well understood. Here we report the kinetics of appearance of FMDV-specific antibody-secreting cells (ASC) in lymphoid organs along the respiratory tract and the spleen in cattle infected by aerosol exposure. While no responses were observed for up to 3 days postinfection (dpi), all animals developed FMDV-ASC in all the lymphoid organs studied at 4 dpi. Tracheobronchial lymph nodes were the most reactive organs at this time, and IgM was the predominant isotype, followed by IgG1. Numbers of FMDV-ASC were further augmented at 5 and 6 dpi, with an increasing prevalence in upper respiratory organs. Systemic antibody responses were slightly delayed compared with the local reaction. Also, IgM was the dominant isotype in serum at 5 dpi, coinciding with a sharp decrease of viral RNA detection in peripheral blood. These results indicate that following aerogenous administration, cattle develop a rapid and vigorous genuine local antibody response throughout the respiratory tract. Time course and isotype profiles indicate the presence of an efficient T cell-independent antibody response which drives the IgM-mediated virus clearance in cattle infected by FMDV aerosol exposure.Instituto de VirologíaFil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Malacari, Darío Amilcar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arzt, J. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados UnidosFil: Pérez Beascoeachea, C. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios; ArgentinaFil: Maradei, E. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios; ArgentinaFil: Rodríguez, L. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados UnidosFil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados UnidosFil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina2018-06-01T13:49:23Z2018-06-01T13:49:23Z2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://jvi.asm.org/content/87/5/2489.longhttp://hdl.handle.net/20.500.12123/25350022-538X1098-5514http://dx.doi.org/10.1128/JVI.02879-12Journal of Virology 87 (5) : 2489-2495. (March 2013)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2024-05-15T12:23:40Zoai:localhost:20.500.12123/2535instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2024-05-15 12:23:41.216INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
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