Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird

Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, l...

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Detalles Bibliográficos
Autores: Levy, Hila, Fiddaman, Steven R., Vianna, Juliana A., Noll, Daly, Clucas, Gemma V., Sidhu, Jasmine K.H., Polito, Michael J., Bost, Charles A., Phillips, Richard A., Crofts, Sarah, Miller, Gary D., Pistorius, Pierre, Bonnadonna, Francesco, Le Bohec, Celine, Barbosa, Andres, Trathan, Phil, Raya Rey, Andrea Nélida, Frantz, Laurent A.F., Hart, Tom, Smith, Adrian L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/141119
Acceso en línea:http://hdl.handle.net/11336/141119
Access Level:acceso abierto
Palabra clave:ANTARCTICA AND SOUTHERN OCEAN
GENTOO PENGUIN
IMMUNOGENETICS
PATHOGEN-MEDIATED SELECTION
POSITIVE SELECTION
TOLL-LIKE RECEPTORS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descripción
Sumario:Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments.

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