Innate immune sensing of cancer: clues from an identified role for type I IFNs

A subset of patients with a variety of cancers shows evidence of a natural adaptive immune response against their tumor, as evidenced by spontaneous T-cell infiltration, circulating anti-tumor T cells, or antibody responses. Evidence has indicated that such natural immune responses have positive pro...

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Detalles Bibliográficos
Autores: Gajewski, Thomas F., Fuertes, Mercedes Beatriz, Woo, Seng Ryong
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/22179
Acceso en línea:http://hdl.handle.net/11336/22179
Access Level:acceso abierto
Palabra clave:Cancer
Linfocitos T Cd8
Interferon
Celulas Dendriticas
Tumor Immunity
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22179
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Innate immune sensing of cancer: clues from an identified role for type I IFNsGajewski, Thomas F.Fuertes, Mercedes BeatrizWoo, Seng RyongCancerLinfocitos T Cd8InterferonCelulas DendriticasTumor Immunityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A subset of patients with a variety of cancers shows evidence of a natural adaptive immune response against their tumor, as evidenced by spontaneous T-cell infiltration, circulating anti-tumor T cells, or antibody responses. Evidence has indicated that such natural immune responses have positive prognostic import in early stage disease and may be predictive of clinical response to immunotherapeutics in advanced disease. However, these observations raise a new critical fundamental question?what innate immune signals might be generated in the context of non-pathogen-induced cancers that drive productive antigen presentation toward induction of an adaptive immune response? Gene expression profiling in melanoma revealed that tumors having high expression of T-cell markers also show evidence of a type I IFN transcriptional signature. Mechanistic experiments in mice have revealed that a spontaneous CD8+ T-cell response against transplantable tumors depends on host type I IFN signaling, through a mechanism dependent upon CD8α+ dendritic cells (DCs). The requirement for type I IFN production by host DCs has suggested a subset of innate immune sensing receptors and signaling pathways that might be involved with initiating this process. Elucidating further these innate immune mechanisms should provide new insights into cancer immunotherapy.Fil: Gajewski, Thomas F.. University Of Chicago; Estados UnidosFil: Fuertes, Mercedes Beatriz. University Of Chicago; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Woo, Seng Ryong. University Of Chicago; Estados UnidosSpringer2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22179Gajewski, Thomas F.; Fuertes, Mercedes Beatriz; Woo, Seng Ryong; Innate immune sensing of cancer: clues from an identified role for type I IFNs; Springer; Cancer Immunology Immunotherapy; 61; 8; 6-2012; 1343-13470340-70041432-0851CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/url/Innate immune sensing of cancer: clues from an identified role for type I IFNsinfo:eu-repo/semantics/reference/doi/10.1007/s00262-012-1305-6info:eu-repo/semantics/reference/pmid/22722449info:eu-repo/semantics/altIdentifier/doi/10.1007/s00262-012-1305-6info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00262-012-1305-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:12:37Zoai:ri.conicet.gov.ar:11336/22179instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:12:38.119CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Innate immune sensing of cancer: clues from an identified role for type I IFNs
title Innate immune sensing of cancer: clues from an identified role for type I IFNs
spellingShingle Innate immune sensing of cancer: clues from an identified role for type I IFNs
Gajewski, Thomas F.
Cancer
Linfocitos T Cd8
Interferon
Celulas Dendriticas
Tumor Immunity
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Innate immune sensing of cancer: clues from an identified role for type I IFNs
title_full Innate immune sensing of cancer: clues from an identified role for type I IFNs
title_fullStr Innate immune sensing of cancer: clues from an identified role for type I IFNs
title_full_unstemmed Innate immune sensing of cancer: clues from an identified role for type I IFNs
title_sort Innate immune sensing of cancer: clues from an identified role for type I IFNs
dc.creator.none.fl_str_mv Gajewski, Thomas F.
Fuertes, Mercedes Beatriz
Woo, Seng Ryong
author Gajewski, Thomas F.
author_facet Gajewski, Thomas F.
Fuertes, Mercedes Beatriz
Woo, Seng Ryong
author_role author
author2 Fuertes, Mercedes Beatriz
Woo, Seng Ryong
author2_role author
author
dc.subject.none.fl_str_mv Cancer
Linfocitos T Cd8
Interferon
Celulas Dendriticas
Tumor Immunity
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Cancer
Linfocitos T Cd8
Interferon
Celulas Dendriticas
Tumor Immunity
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description A subset of patients with a variety of cancers shows evidence of a natural adaptive immune response against their tumor, as evidenced by spontaneous T-cell infiltration, circulating anti-tumor T cells, or antibody responses. Evidence has indicated that such natural immune responses have positive prognostic import in early stage disease and may be predictive of clinical response to immunotherapeutics in advanced disease. However, these observations raise a new critical fundamental question?what innate immune signals might be generated in the context of non-pathogen-induced cancers that drive productive antigen presentation toward induction of an adaptive immune response? Gene expression profiling in melanoma revealed that tumors having high expression of T-cell markers also show evidence of a type I IFN transcriptional signature. Mechanistic experiments in mice have revealed that a spontaneous CD8+ T-cell response against transplantable tumors depends on host type I IFN signaling, through a mechanism dependent upon CD8α+ dendritic cells (DCs). The requirement for type I IFN production by host DCs has suggested a subset of innate immune sensing receptors and signaling pathways that might be involved with initiating this process. Elucidating further these innate immune mechanisms should provide new insights into cancer immunotherapy.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22179
Gajewski, Thomas F.; Fuertes, Mercedes Beatriz; Woo, Seng Ryong; Innate immune sensing of cancer: clues from an identified role for type I IFNs; Springer; Cancer Immunology Immunotherapy; 61; 8; 6-2012; 1343-1347
0340-7004
1432-0851
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22179
identifier_str_mv Gajewski, Thomas F.; Fuertes, Mercedes Beatriz; Woo, Seng Ryong; Innate immune sensing of cancer: clues from an identified role for type I IFNs; Springer; Cancer Immunology Immunotherapy; 61; 8; 6-2012; 1343-1347
0340-7004
1432-0851
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference/url/Innate immune sensing of cancer: clues from an identified role for type I IFNs
info:eu-repo/semantics/reference/doi/10.1007/s00262-012-1305-6
info:eu-repo/semantics/reference/pmid/22722449
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00262-012-1305-6
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00262-012-1305-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,811543

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