Cytokines and chronic liver disease
From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate...
| Authors: | , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2007 |
| Country: | Argentina |
| Institution: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repository: | CONICET Digital (CONICET) |
| Language: | English |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/177912 |
| Online Access: | http://hdl.handle.net/11336/177912 |
| Access Level: | Open access |
| Keyword: | CYTOKINES HEPATITIS KUPFFER CELLS LIVER TOLEROGENIC RESPONSES https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| Summary: | From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations. |
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