Administration of a Peptide Inhibitor of α4-Integrin Inhibits the Development of Experimental Autoimmune Uveitis

Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Inte...

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Detalles Bibliográficos
Autores: Martín, Andrea P., Vieira de Moraes, Luciana, Tadokoro, Carlos E., Commodaro, Alessandra G., Urrets Zavalía, Enrique Alberto, Rabinovich, Gabriel A., Urrets Zavalía, Julio, Rizzo, Lucio V., Serra, Horacio M.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2005
País:Argentina
Institución:Universidad Católica de Córdoba
Repositorio:Producción Académica (UCC)
Idioma:español
OAI Identifier:oai:pa.bibdigital.uccor.edu.ar:4272
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4272/1/A_Martin_Vieira_R.pdf
Access Level:acceso abierto
Palabra clave:RE Oftalmología
Descripción
Sumario:Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.

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